http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2355526-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae10212794160b34478f0d05b6ab6fd7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 2006-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e606b25eee911f191e13443c1e8b4a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d49d8d4d36887257fed3ebd666549f3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57428b9f771fe2ba85ff4fa4a7b0312f |
| publicationDate | 2011-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2355526-T3 |
| titleOfInvention | METHODS AND COMPOSITIONS THAT USE IMMUNOMODULATING COMPOUNDS FOR THE TREATMENT OF ASSOCIATED DISORDERS AT LEPTINE LEVELS IN LOW PLASMA. |
| abstract | An immunomodulatory compound, or a pharmaceutically acceptable salt, a solvate or a stereoisomer thereof, for use in the treatment, care or prevention of a disorder associated with a hypolepinemic state, or a symptom thereof, wherein the disorder is a metabolic or eating disorder, neuroendocrine dysfunction related to hypoleptinemia, immunodeficiency related to hypoleptinemia, hypothalamic amenorrhea, acromegaly, infertility syndrome related to hypoleptinemia, skin damage, wounds, long-term hemodialysis or hair loss; and wherein the immunomodulatory compound is of (a) formula (I): ** (See formula) ** in which one of X and Y is C = O, the other of X and Y is C = O or CH2, and R2 is hydrogen or methyl; or (b) formula (II): ** (See formula) ** in which one of X and X is C = O and the other is CH2 or C = O; R1 is H, (C1-C8) alkyl, (C3-C7) cycloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, benzyl, aryl, (C0-C4) alkyl-(C1-C6) alkyl, (C0-C4) alkyl (C2-C5) heteroaryl, C (O) R3, C (S) R3, C (O) OR4, (C1-C8) alkyl -N (R6) 2, (C1-C8) alkyl ) -OR5, (C1-C8) alkyl -C (O) OR5, C (O) NHR3, C (S) NHR3, C (O) NR3R3 ', C (S) NR3R3'or (C1-C8) alkyl - O (CO) R5; R2 is H, F, benzyl, (C1-C8) alkyl, (C2-C8) alkenyl or (C2-C8) alkynyl; R3 and R3 'are independently (C1-C8) alkyl, (C3-C7) cycloalkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, benzyl, aryl, (C0-C4) alkyl-(C1-C6) alkylcycloalkyl ), (C0-C4) -heteroaryl (C2-C5) alkyl, (C0-C8) -N (R6) 2, (C1-C8) -OR5 alkyl, (C1-C8) -C (O) OR5 alkyl , (C1-C8) -O (CO) R5 or C (O) OR5 alkyl; R4 is (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C1-C4) -OR5 alkyl, benzyl, aryl, (C0-C4) -heterocycloalkyl (C1-C6) alkyl or (C0-C4) alkyl-heteroaryl (C2-C5); R5 is (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, benzyl, aryl or heteroaryl (C2-C5); each presence of R6 is independently H, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, benzyl, aryl, (C2-C5) heteroaryl or (C0-C8) -C (O alkyl) ) O-R5, or the R6 groups join to form a heterocycloalkyl group; n is 0 or 1; and * represents a chiral carbon center. |
| priorityDate | 2005-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 591.