| abstract |
A modified Neisseria meningitidis strain characterized in that said strain can be obtained using the following procedures: d) a method of detoxifying the lipid portion A of the LPS within the strain, which comprises the steps of identifying an msbB gene involved in causing the portion of lipid A of the LPS is toxic and genetically engineered the strain to reduce or deactivate the expression of said gene; and h) a procedure of genetic engineering modification of the strain so that it lacks capsular polysaccharide. |