| abstract |
An acylated 1,2,3,4-tetrahydronaphthylamine according to the general formula (I) in any of its stereisomeric forms or mixtures thereof in any proportion, or its pharmaceutically acceptable salt, in which R 1 and R 4 are independently selected from each other. from the group consisting of: H, halogen and C1-C4 alkyl; R 2 and R 3 are H; A and B are CH2; C is CH2 or CH-CH3; R 5 is a Hetar group that may not be substituted or carry one or more substituents selected from the group consisting of: F; Cl; Br; C1-C3 alkyl; (C1-C3 alkoxy) methyl; CF3; phenyl; benzyl; OH; C1-C3 alkoxy; phenoxy; trifluoromethoxy; 2,2,2-trifluoroethoxy; NH2; (C1-C4 alkyl) amino; di (C1-C4 alkyl) amino; (C1-C3 alkyl) -CONH-; (C1-C3 alkyl) -SO2NH-; (C1-C3 alkyl) -CO; phenyl-CO; -OCH2O-; -OCF2O-; and CN; and wherein all phenyl and phenyl-containing groups, which are optionally present in said substituents of said Hetar group, may be substituted with one or more substituents selected from the group consisting of halogens, CN, C1-C3 alkyl, OH, C1-C3 alkoxy, and CF3; The Hetar group is a residue of an aromatic heterocycle selected from the group consisting of: pyrrole, furan, thiophene, imidazole, pyrazole, oxazol, isoxazole, thiazole, isothiazole, pyridine, pyridazine, pyrimidine, pyrazine, indole, benzothiophene, benzofuran, benzothiazole , benzoimidazole, benzodioxole, quinoline, isoquinoline, cinnoline, quinazoline, and quinoxaline; with the proviso that, in the case where R 1, R 2, R 3 and R 4 are hydrogen, R 5 is not unsubstituted pyridyl or substituted or unsubstituted 4oxoquinolinyl. |