http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2354917-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6774d64d8418a81f2d538355d96a31b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4168 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-44 |
| filingDate | 2007-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1b0a3c750f418a4889f3ed6251ba343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7c10522c80798ac3b8615f36e2930c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59cb7d747d738bc724a73f8208bb391f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_860785e599478454ef5207932e5ae44d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9589e725574f2998a35ac9440d331cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39b9b44c15c32ab186eb54dfc6f7781c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3b130131dd4574e621e6f846979b5f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c62f9a50db39eba7d8aa4509fcdaf349 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dc641911b65a59da728e900a14190cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eab1a553276208924f8c832e4dd06cab |
| publicationDate | 2011-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2354917-T3 |
| titleOfInvention | ACTIVATORS OF BENZAMIDAGLUCOQUINASA. |
| abstract | A pharmaceutical composition comprising a compound of formula I or a salt thereof: ** Formula ** in which B is a direct bond or -O-; R1 is C1-6 alkyl, C1-4 alkoxy C1-4 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-4 alkyl or C3-7 cycloalkyl -oxy-C1-4 alkyl, each of which is optionally substituted with one or more substituents independently selected from R3; R3 is independently selected from hydroxy, -CF3, methyl or F; X is a connector independently selected from -OZ- or -OZOZ-, in which O is attached to the phenyl ring, each Z being independently selected from a direct bond, C2-6 alkenylene and - (CH2) pC (R10) 2- (CH2) q-; Y is selected from aryl-Z1-, a 5-10 membered heterocyclyl-Z1-, the heterocycle consisting of carbon atoms and 1-4 heteroatoms selected from O, N, and S (O) t, C3-7 cycloalkyl. - Z1-, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, - (CH2) 1-4CH2F, - (CH2) 1-4CHF2, - (CH2) 1-4CF3, -CH (OH) CH2F, -CH (OH) CHF2 and -CH (OH) CF3, in which each Y is optionally substituted with 1-3 substituents independently selected from R4; Z1 is independently selected from a direct bond, C2-6 alkenylene and - (CH2) p-C (R10) 2- (CH2) q-; p is independently selected from 0, 1, 2 and 3; q is independently selected between 0, 1, 2 and 3; p + q is selected between 0, 1, 2 and 3; R4 is independently selected from R5-X1, Cl, F, Br, I, CH2F, CHF2, CF3, cyano, amino, C1-6 alkyl, -O-C1-6 alkyl, carboxy, -C (O) OR7, hydroxy and phenyl optionally substituted with C1-6 alkyl or -C (O) OR7, with X1 being defined above as X; R5 is selected from H, C1-6 alkyl, CH2F, CHF2, CF3, phenyl, naphthyl, a 5-10 membered heterocyclyl consisting of carbon atoms and 1-4 heteroatoms selected from 5 O, N, and S (O) t, and a C3-7 cycloalkyl, and each R5 is optionally substituted with one or more substituents selected from R6; R6 is independently selected from Cl, F, Br, I, C1-6 alkyl, -O-C1-6 alkyl, CH2F, CHF2, CF3, cyano, hydroxy, amino, C (O) OH or -C (O) O -C 1-6 alkyl; R7 is independently selected from C1-8 alkyl and C3-8 cycloalkyl; A is ** Formula ** R8 is independently selected from - (CH2) 1-2-COOH, optionally substituted with one or more substituents independently selected from R9; R9 is independently selected from C1-4 alkyl, hydroxy or F; R10 is independently selected from H, Cl, F, Br, I, C1-6 alkyl and -C2-4 alkyl-C1-4alkyl; t is independently selected from 0, 1 and 2; and a pharmaceutically acceptable diluent or carrier. |
| priorityDate | 2006-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1164.