http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2354909-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 |
| filingDate | 2006-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83413618aa6a15ca8b99b862f10a8ecf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc9f9cbb162afca27e17d0e0de210e59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f811184bcd368b898cfc7aaf03ea193 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9709d20d9e46d0d882816ef2f63447fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acfdeacfcc9e535e74d2fec830e5bd95 |
| publicationDate | 2011-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2354909-T3 |
| titleOfInvention | DERIVATIVES OF INDOL-3-IL-CARBONIL-AZAESPIRO AS RECEIVING ANTAGONISTS OF VASOPRESIN. |
| abstract | A compound of the following general formula (I): C1-6 alkyl, R 2 ANR 1 OR 3 aryl, 5- or 6-link heteroaryl or sulfonylaryl, each of which is optionally substituted by one or more B, - (CH2 ) mR a, in which R a is: CN, OR i, NR i R ii, C3-6 cycloalkyl, 4-7 link heterocycloalkyl, 5 or 6 link aryl or heteroaryl, each of which is optionally substituted by one or several B, - (CH2) n- (CO) -R bo - (CH2) n- (SO2) -R b, in which R b is: C1-6 alkyl, C1-6 alkoxy, C3 cycloalkyl -6, - (CH2) m-NR iii R iv, NR i R ii, C3-6 cycloalkyl, 4-7 link heterocycloalkyl, 5 or 6 link aryl or heteroaryl, each of which is optionally substituted by one or several B, or R 1 and R 3 together with the indole ring to which they are attached form a 5 or 6 link heterocycloalkyl which is optionally substituted by = O; there is one or several R 2, each R 2 according to its appearance is the same or different, R 2 is one or more H, OH, halogen, CN, nitro, C1-6 alkyl optionally substituted by -NR iii R iv, (I) C1-6 alkoxy, -O-CH2-C2-6 alkenyl or benzyloxy, or two R2 together with the indole ring to which they are attached form an oxo or dioxo bridge; R 3 is H, halogen, - (CO) -R c, where R c is: C1-6 alkyl, - (CH2) n-NR i R ii, - (CH2) n-NR iii R iv or heterocycloalkyl 5 or 6 links optionally substituted by C1-6 alkyl, or C1-6 alkyl or aryl, each of which is optionally substituted by halogen, B is halogen, CN, NR and R ii, -O (CO) -alkyl C1-6 or -NH (CO) R d, wherein R d is C1-6 alkyl optionally substituted by halogen or nitro, or R d is aryl or heteroaryl of 5 or 6 links, each of which is optionally substituted by halogen, nitro, C1-6 alkyl or C1-6 haloalkyl; C1-6 alkyl optionally substituted by CN, halogen or C1-6 alkoxy, C1-6 alkoxy, C1-6 haloalkoxy, C3-6 cycloalkyl, -C (O) O-C1-6 alkyl, -C (O) NR i R ii, -C (O) -C 1-6 alkyl, -S (O) 2-C 1-6 alkyl, -S (O) 2- NR i R ii or (CR iii R iv) n-phenyl or (CR iii R iv) 5 or 6-link n-heteroaryl, in which the 5 or 6-link phenyl or heteroaryl moiety is optionally substituted by one or more substituents, chosen from the group consisting of: halogen, CN, NR and R ii , C1-6 alkyl optionally substituted by CN or C1-6 alkoxy, C1-6 alkoxy, C1-6 haloalkoxy, C3-6 cycloalkyl, -C (O) O-C1-6 alkyl, -C (O) -NR i R ii, -C (O) -C 1-6 alkyl, -S (O) 2-C 1-6 alkyl and -S (O) 2- NR i R ii; R i and R ii independently of each other are H, C1-6 alkyl, (C1-6 alkyl) -NR iii R iv, - (CO) O-C1-6 alkyl, -C (O) -NR iii R iv, -C (O) C1-6 alkyl, -S (O) 2-C1-6 alkyl or -S (O) 2- NR iii R iv; R iii and R iv independently of each other are H or C1-6 alkyl; m is a number from 1 to 6; n is a number from 0 to 4; A is a group of the formula (a) or of (b): in which R 4 is H or C 1-6 alkyl; O R 4 R 5 is aryl optionally substituted by halogen; or a pharmaceutically acceptable salt thereof, N N N R N (a) (b) with the proviso that compounds with group A (b) and R 1 = R 2 = R 3 = H are excluded; and the compounds with group A (b) and R 2 = OH, C 1-6 alkoxy, or benzyloxy in the 5-position of the indole. |
| priorityDate | 2005-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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