http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2354653-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a337518529646de8eb77d09e4a1f88b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate | 2007-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fe55d85ca7a107da7e1f41ea3a9556c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec1afdf87f9ee809b79eb39ab03ba6c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8c62ec0d40de594a554e47b2a283ba8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ecc2d5605c0c39e2bd4ddb5fc759fdf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d27deb2dc943fcc30c1563690503814 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffaec2b1e805f941e367db772a6a3f3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29e157afd3a400cf70d0f27d63cf4f11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d59ee0dadcc202dcea7ea30f8188d62b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1fd0cf3bf2da748c171d25b4ee2632f |
| publicationDate | 2011-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2354653-T3 |
| titleOfInvention | LACRIMAL LIPOCALINE MUTEINS AND PROCEDURES TO OBTAIN THE SAME. |
| abstract | A method for generating a human tear lipocalin mutein, in which the mutein binds to a given unnatural ligand of human tear lipocalin with detectable binding affinity, comprising: (a) subjecting a nucleic acid molecule that encodes a human tear lipocalin to mutagenesis in at least 12, 14 or 16 of the codons of any of the positions of amino acid sequence 26-34, 56-58, 80, 83, 104-106 and 108 of the linear polypeptide sequence of the native mature human tear lipocalin, in which at least one of the codons encoding cysteine residues at sequence positions 61 and 153 of the linear polypeptide sequence of the mature human tear lipocalin has been mutated to encode any other amino acid residue , thereby obtaining a plurality of nucleic acids encoding human lacrimal lipocalin muteins, (b) expressing the one or more mutein nucleic acid molecules obtained s in (a) in an expression system, thereby obtaining one or more muteins and (c) enriching the one or more muteins obtained in step (b) and having binding affinity detectable by a given unnatural ligand of human tear lipocalin by means of selection and / or isolation, provided that the unnatural ligand of human tear lipocalin is not the CD4 human T lymphocyte co-receptor. |
| priorityDate | 2006-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 477.