http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2354569-T3
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 |
| filingDate | 2006-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dee4eb7e00c71585bff81b260e3007f9 |
| publicationDate | 2011-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2354569-T3 |
| titleOfInvention | HISTAMINE RECEIVER ANTAGONISTS-3. |
| abstract | A compound of formula Ia or Ib ** Formula ** or a pharmaceutically acceptable salt thereof, or the cis isomer, the trans isomer, or a mixture of cis and trans isomers, in which: R1 is selected from the group consisting in OR4 and NR2R3; each of R2 and R3 is independently selected from the group consisting of hydrogen; C1-C8 alkyl optionally substituted with 1 to 4 halogens; C1-C4 alkyl group optionally substituted with a substituent selected from the group consisting of OH, from one to four C1-C4 alkyl, C3-C7 cycloalkyl, C1-C4 dialkylamino, C6-C14 aryl optionally substituted with a halogen or C6 aryloxy -C10 optionally substituted with one to two halogens, and 5-10 membered heteroaryl optionally substituted with a C6-C10 aryl group and optionally substituted with one to three C1-C4 alkyl groups; C3-C7 cycloalkyl; C6-C14 aryl; 3-8-membered heterocycloalkyl optionally substituted with one or more C1-C4 alkylcarbonyl groups; C6-C10 arylsulfonyl optionally substituted with one or more C1-C2 alkyl; 5-10 membered heteroaryl; C6-C14-C0-C4-O-C0-C4-alkyl alkylene, wherein each C0-C4 alkyl and each C0-C4 alkylene is optionally substituted with one to four C1-C4 alkyl; -C (= O) R3, -S (O) 2R3 '; wherein R3 'is selected from the group consisting of hydrogen, (C1-C4) alkyl, alkenyl (C1-C4), aryl, heteroaryl, cycloalkyl (C3-C7), cycloheteroalkyl (C3-C7), and in the that each hydrogen in R3 'can be optionally independently substituted with halo, (C1-C4) alkyl, (C2-C4) alkenyl and -S (O) 2CH3; wherein R3 25 can be further selected from the group consisting of C6-C14 arylcarbonyl-C6-C14 aryl; C 3-8 arylcarbonyl 3-8 membered heterocycloalkyl; C3-C8 cycloalkylcarbonyl-C6-C14 aryl; 3-8 membered C3-C8-cycloalkylcarbonyl heterocycloalkyl; 3-8 membered heterocycloalkylcarbonyl-C6-C14 aryl; and 3-8-membered heterocycloalkylcarbonyl-3-8-membered heterocycloalkyl; or R3 and R2 together with the nitrogen of the NR2R3 group form a first 5, 6 or 7 member aliphatic ring, in which one of the carbons in the first 5, 6 or 7 member aliphatic ring is optionally replaced by O, S , NR2 'or CO, and the first 5, 6 or 7 membered aliphatic ring is condensed with a C6-C10 arylene and is optionally substituted on a ring carbon with a substituent selected from the group consisting of 5-10 heteroaryl members optionally substituted with one or more halogens and optionally substituted with one or more C1-C2 alkyl, C1-C4 alkoxy optionally substituted with one or more C1-C2 alkoxy and optionally substituted with one or more C1-C4 dialkylaminocarbonyl, and one or two C1-C4 alkyl optionally and independently substituted with one or more C1-C2 alkoxy; in which R2 'is hydrogen; C1-C8 alkyl optionally substituted with 1 to 4 halogens; 5-10 membered heteroaryl optionally substituted with a substituent selected from the group qu5 e consists of halogen, C1-C4 alkyl, C1-C2 alkoxy, C6-C10 aryl, C1-C4 alkylaminocarbonyl, and cyano; C1-C4 alkyl group optionally substituted with a substituent selected from the group consisting of C1-C2-alkoxycarbonyl, 5-10 membered heteroaryl optionally substituted with one or more C1-C2 alkyl, from one to four C1-C4 alkyl, C3-C7 cycloalkyl and C6-C14 aryl; C6-C10 aryl optionally substituted with one or two C1-C2 alkyl; C1-C4 alkylcarbonyl; or C6-C14-C0-C4-O-C0-C4-alkyl alkylene, wherein each C0-C4 alkyl and each C0-C4 alkylene is optionally substituted with one to four C1-C4 alkyl; C1-C4 alkylsulfonyl R4 is hydrogen or methyl; each of R5 and R6 is independently selected from the group consisting of hydrogen; C1-C4 alkyl group optionally substituted with a substituent selected from the group consisting of OH, C1-C3 alkyl, C1-C3 alkoxy; or R5 and R6 together with the nitrogen to which they are attached form a 3-7 membered cyclic amine optionally substituted with one or more C1-C4 alkyl; R7 is independently hydrogen or methyl; n is 1, 2 or 3; m is 1, 2 or 3; Z is independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy and -C (H) = CH2; or wherein, when m is 2 and both Z are -C (H) = CH2, both Z together with 2 adjacent carbons or the phenyl ring of formula I form a 6-membered aromatic ring fused to said phenyl ring. |
| priorityDate | 2005-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 80.