http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2354278-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36002650e924d3edaec88b4324ca7e83 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-216 |
| filingDate | 2006-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_519e1aa05bd3e1f56747e64208262c21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8469389936e5ebdf5a929ea8056b1063 |
| publicationDate | 2011-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2354278-T3 |
| titleOfInvention | PHARMACEUTICAL FORMULATION OF NITROXIDERIVATE OF NSAIDs. |
| abstract | A pharmaceutical formulation comprising: a) one or more NSAIDs that release NO of formula (I); b) one or more surfactants where the surfactant ratio: NSAIDs that release is NOT 0.1: 1 to 10: 1; c) a carbonyl capturing compound selected from the forms of free acids, salts, carboxylic acid esters derived from a compound of formula (II) H2N- (CH2) m- (C6H4) -COOH (II) where m = 0- Wherein the amount of the compound of formula (II) is from about 0.01% to about 5% by weight of the total weight of the composition; where in formula (I) M is selected from the group consisting of X is a spacer, that is, a compound that forms a bridge between the nitrogen oxide donor group and the NSAID, and is selected from i) C1-C20 alkylene linear or branched, preferably C1-C10, being optionally substituted with one or more of the substituents selected from the group consisting of: halogen, hydroxy, -ONO2 or T atoms, where T is -OC (O) (C1-C10 alkyl ) -ONO2 or -O (C1-C10 alkyl) -ONO2; ii) a C5-C7 cycloalkylene group optionally substituted with a linear or branched C1-C10 alkyl group, preferably CH3; iii) where n is an integer from 0 to 20, preferably n is an integer from 0 to 5; and n 1 is an integer from 1 to 20, preferably n 1 is an integer from 1 to 5; with the proviso that the -ONO2 group of formula (I) is linked to - (CH2) n 1; and iv) where X2 is -O- or -S-; n 3 is an integer from 1 to 6, preferably from 1 to 4, and R 2 is H or CH3. |
| priorityDate | 2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.