| abstract |
A compound having the formula I or a pharmaceutically acceptable salt thereof or stereoisomeric forms thereof, wherein: R 1 is hydrogen, R 2 is hydrogen or C1-20 alkyl, R 3 is hydrogen, C1-20 alkyl, cycloalkyl C4-8, C5-8 cycloalkenyl, aryl, aromatic or non-aromatic heterocycle, C1-20 alkoxy, or a group of formula -W- R 8. R 3a is hydrogen, C1-20 alkyl or a group of formula: or NR 3 R 3a is a group of formula R 4 is hydrogen, R 5 is halogen or trifluoromethyl, R 6 is hydrogen, C1-20 alkyl or halogen, R 7 is hydrogen, C1-20 alkyl or halogen, W is C1-12 alkylene, -NH- or -NHC (= O) -, X is O, S or NH, Y is O, S, -CR 12 R 13 - , -NR 14 - or -C (= O) -, R 8 is aryl or heterocycle, R 9, R 10, R 10a and R 11 are independently selected from hydrogen, C 1-4 alkyl, halogen, hydroxy or methoxycarbonyl, or R 10 and R 10a together form a C3-6 alkylene, R 12 is hydrogen, C1-4 alkyl, halogen or hydroxy, R 13 is hydrogen, or CR 12 R 13 is dioxolanyl, R 14 is aryl, heterocycle or a group of formula -VR 15, V is C1-12 alkylene, R 15 is aryl or heterocycle, m is 1 to 4, n is 0 or 1. |