http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2352748-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e673458c8c443e6fcd34bbc9565bf7f7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 |
| filingDate | 2005-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24b0c6376a6e4e3aa844d5e119d6604a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_305c0ea0148396d872842a67a79892fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48a028061559bb380d5d7ebdf994c624 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf72105c3bd8de5f3cbc2acc5fae3fc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17e3b563c8eb8abdcfccd8b75ce734f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a51cd51b95a6a81eff12bdd2a3531183 |
| publicationDate | 2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2352748-T3 |
| titleOfInvention | PHENYLAMINOPIRIDINS AND PHENYLAMINOPIRACINES. |
| abstract | Compounds of formula (I) ** (See formula) ** where A is CH, C-C1-C7 alkyl or N; R1 represents C (= O) R9, S (= O) 2R10, P (= O) (O11) 2, optionally substituted phenyl or optionally substituted heteroaryl; R2 represents hydrogen or C1-C7 alkyl; R3 represents one or two substituents independently selected from the group consisting of hydrogen, C1-C7 alkyl, cycloalkyl, heterocyclyl, hydroxy-C1-C7 alkyl, halo-C1-C7 alkyl, C1-C7 alkoxy-C1-C7 alkyl, C1- alkoxy C7-C1-C7 alkoxy-C1-C7 alkyl, halo-C1-C7 alkoxy-C1-C7 alkyl optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, C1-C7 alkoxy, halo-C1-C7 alkoxy , C1-C7 alkoxy-C1-C7 alkoxy, alkenyloxy, aryloxy, heteroaryloxy, alkylmercapto, alkylsulfinyl, haloC1-C7 alkylsulfinyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, hydroxy, amino, C1-C7 alkylamino, di-alkylamino C1-C7 alkylcarbonylamino, C1-C7 alkylcarbonyl, optionally substituted phenylcarbonyl, carboxyl, C1-C7 alkoxycarbonyl, C1-C7 alkoxy-C1-C7 alkoxycarbonyl; aminocarbonyl wherein amino is unsubstituted or substituted by one or two substituents chosen from C1-C7 alkyl, cycloalkyl, cycloalkyl-C1-C7 alkyl, hydroxyalkyl C1-C7, C1-C7 alkoxy-C1-C7 alkyl, optionally substituted phenyl, phenyl optionally substituted C1-C7 alkyl, optionally substituted heteroaryl and optionally substituted heteroaryl-C1-C7 alkyl, or wherein the two nitrogen substituents form together with the heterocyclyl nitrogen; cyano, halogen, and nitro; R4 and R5, independently, represent hydrogen, C1-C7 alkyl, halo-C1-C7 alkyl, C1-C7 alkoxy, amino or halogen; R6 represents hydrogen, C1-C7 alkyl, C1-C7 alkylcarbonyl or C1-C7 alkoxycarbonyl; R7 represents one or two substituents independently selected from the group consisting of hydrogen, C1-C7 alkyl, cycloalkyl, heterocyclyl, hydroxy-C1-C7 alkyl, halo-C1-C7 alkyl, C1-C7 alkoxy-C1-C7 alkyl, C1- alkoxy C7-C1-C7 alkoxy-C1-C7 alkyl, halo-C1-C7 alkoxy-C1-C7 alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, C1-C7 alkoxy, halo C1-alkoxy C7, C1-C7 alkoxy-C1-C7 alkoxy, alkenyloxy, aryloxy, heteroaryloxy, alkylmercapto, alkylsulfinyl, halo-C1-C7 alkylsulfinyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, hydroxy, amino, C1-C7 alkylamino, di-C7-C7-alkylamino , C1-C7 alkylcarbonylamino, C1-C7 alkylcarbonyl, optionally substituted phenylcarbonyl, carboxyl, C1-C7 alkoxycarbonyl, C1-C7 alkoxy-C1-C7 alkoxycarbonyl; aminocarbonyl wherein amino is unsubstituted or substituted by one or two substituents chosen from C1-C7 alkyl, cycloalkyl, cycloalkyl-C1-C7 alkyl, hydroxy-C1-C7 alkyl, C1-C7 alkoxy-C1-C7 alkyl, optionally phenyl substituted, optionally substituted phenyl-C1-C7 alkyl, optionally substituted heteroaryl and optionally substituted heteroaryl-C1-C7 alkyl, or wherein the two substituents on the nitrogen together with the heterocyclyl nitrogen; cyano, halogen and nitro; R8 represents hydrogen, C1-C7 alkoxy, hydroxy, C1-C7 alkyl, C1-C7 alkylcarbonyloxy, C1-C7 alkoxycarbonyl, aminocarbonyl, C1-C7 alkylaminocarbonyl, di-alkylaminocarbonyl C1-C7, amino, C1-C7 alkylamino, di-alkylamino C1-C7, halogen, cyano or nitro; R9 represents C1-C7 alkyl, halo-C1-C7 alkyl, cycloalkyl-C1-C7 alkyl, heterocyclyl-C1-C7 alkyl, hydroxy-C1-C7 alkyl, C1-C7 alkoxy-C1-C7 alkyl, C1-C7 alkoxycarbonyl C1-C7 alkyl, aminocarbonyl-C1-C7 alkyl, alkylaminocarbonyl C1-C7-C1-C7 alkyl, di-alkylaminocarbonyl C1-C7-C1-C7 alkyl, carboxy-C1-C7 alkyl, aminoalkyl wherein amino is unsubstituted or substituted by one or two substituents chosen from C1-C7 alkyl, hydroxy-C1-C7 alkyl, alkoxy-C1-C7 alkyl, amino-C1-C7 alkyl, C1-C7 alkylcarbonyl, C1-C7 alkoxycarbonyl, C1-C7 amino-alkoxycarbonyl, C1-C7 alkoxy-C1-C7 alkoxycarbonyl and aminocarbonyl, or wherein the two substituents in the nitrogen together with the heterocyclyl nitrogen; optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl in which alkyl is unsubstituted or substituted by hydroxyl, C1-C7 alkyl, halo-C1-C7 alkyl, C1-C7 alkoxy, amino, C1-C7 alkylamino, C1-C7 di-alkylamino, C1-C7 alkylcarbonyloxy, aminocarbonyloxy, C1-C7 alkylaminocarbonyloxy, C1-C7 di-alkylaminocarbonyloxy or halogen; optionally substituted heteroarylalkyl wherein alkyl is unsubstituted or substituted by hydroxyl, C1-C7 alkyl, halo-C1-C7 alkyl, C1-C7 alkoxy, amino, C1-C7 alkylamino, C1-C7 di-alkylamino, C1-C7 alkylcarbonyloxy, aminocarbonyloxy, C1-C7 alkylaminocarbonyloxy, di-C1-C7 alkylcarbonyloxy or halogen; R10 represents C1-C7 alkyl, halo-C1-C7 alkyl, cycloalkyl-C1-C7 alkyl, heterocyclyl-lower alkyl, hydroxy-C1-C7 alkyl, C1-C7 alkoxy-C1-C7 alkyl, C1-C7 alkoxycarbonyl-C1 -C7, aminocarbonyl-C1-C7 alkyl, alkylaminocarbonyl C1-C7-C1-C7 alkyl, di-alkylaminocarbonyl C1-C7-C1-C7 alkyl, carboxy-C1-C7 alkyl, aminoalkyl wherein amino is unsubstituted or substituted by one or two substituents selected from C1-C7 alkyl, hydroxy-C1-C7 alkyl, alkoxy-C1-C7 alkyl, amino-C1-C7 alkyl, C1-C7 alkylcarbonyl, C1-C7 alkoxycarbonyl, C1-C7 amino-alkoxycarbonyl, C1 alkoxy -C7-C1-C7 alkoxycarbonyl and aminocarbonyl, or wherein the two substituents in the nitrogen together with the heterocyclyl nitrogen; optionally substituted alkenyl, cycloalkyl, heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl or optionally substituted heteroarylalkyl; R11 represents C1-C7 alkyl, halo-C1-C7 alkyl, C1-C7 alkoxy-C1-C7 alkyl, aryl or aryl-C1-C7 alkyl; and its salts; with the proviso that, if R1 is C (= O) R9 or S (= O) 2R10, R3, R4, R5 and R6 are all hydrogen, a) A is CH, R7 is hydrogen and R8 is hydrogen, methoxy, chlorine or cyano, b) A is CH, R 7 is 3-chloro and R 8 is fluoro, c) A is CH or N, R 7 is two methoxy substituents in positions 3 and 5 and R 8 is methoxy; then R9 or R10 cannot be methyl. |
| priorityDate | 2004-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 216.