http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2352320-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6f10141ac5f791e5b04c0489b69a95e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 |
| filingDate | 2007-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d900e6ee75e7f3265a590c47fc7107af |
| publicationDate | 2011-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2352320-T3 |
| titleOfInvention | NEW PROCEDURE FOR THE SYNTHESIS OF 2-AMINOXAZOL COMPOUNDS. |
| abstract | Process for the preparation of compounds of formula (I), which comprises a condensation of a compound of formula (II) and an amide derivative of formula (III), in a solvent comprising a base: ** (See formula) * * Where: R1, R2, R3, R4 and R5 are independently selected from hydrogen, halogen selected from F, Cl, Br or I, a linear or branched alkyl group containing 1 to 10 carbon atoms and optionally substituted by one or more heteroatoms such as halogen selected from F, Cl, Br or I, oxygen and nitrogen, the latter optionally in the form of an amino group, as well as a trifluoromethyl group, C1 to C6 alkyloxy, amino, C1 to C6 alkylamino, dialkylamino C1 to C6, carboxyl, cyano, nitro, formyl, hydroxy and CO-R, COO-R, SO2-R and SO2NH-R where R is a linear or branched alkyl group containing 1 to 10 carbon atoms and optionally substituted by at least one heteroatom, especially a halogen selected from F, Cl, Br or I, oxygen and nitrogen, the latter optionally in the form of an amino group. R6 and R7 are independently selected from: (i) hydrogen, a halogen selected from F, Cl, Br or I, or (ii) an alkyl group defined as a linear, branched or cycloalkyl group containing from 1 to 10 carbon atoms and optionally substituted by one or more heteroatoms as halogen selected from F, Cl, Br or I, oxygen and nitrogen, the latter optionally in the form of an amino group, as well as trifluoromethyl, carboxyl, cyano, nitro, formyl; as well as CO-R, COO-R, SO2-R and SO2NH-R where R is a linear or branched alkyl group containing from 1 to 10 carbon atoms and optionally substituted by at least one heteroatom, especially halogen selected from F, Cl, Br or I, oxygen and nitrogen, the latter optionally in the form of an amino group; as well as a cycloalkyl, aryl1 or heteroaryl1 group optionally substituted by a basic nitrogen radical, or (iii) An aryl1 group defined as a phenyl group or a substitution derivative thereof with any combination, in any ring position, of one or more substituents such as: - Halogen selected from I, F, Cl or Br; - An alkyl group1; - A cycloalkyl or aryl group optionally substituted by a nitrogen or amino group; - Trifluoromethyl, O-alkyl1, carboxyl, cyano, nitro, formyl, hydroxy, NH-alkyl1, N (alkyl1) (alkyl1) and amino, the latter nitrogen substituents optionally in the form of a basic nitrogen radical; - NHSO2-R or NHSO2NH-R or CO-R or COO-R or SO2-R or SO2NH-R where R corresponds to hydrogen, alkyl1, aryl or (iv) A heteroaryl group1 defined as a pyridyl, pyrimidinyl, pyrazinyl group, pyridazinyl, thienyl, thiazolyl, imidazolyl, pyrazolyl, pyrrolyl, furanyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl, indolyl, benzimidazole or quinolinyl, which can additionally carry any combination, in any ring position, of one or more substituents such as: - Halogen selected from F, Cl, Br or I; - An alkyl group 1: - A cycloalkyl or aryl group optionally substituted by a nitrogen or amino group; - Trifluoromethyl, O-alkyl1, carboxyl, cyano, nitro, formyl, hydroxy, NH-alkyl1, N (alkyl1) (alkyl1), and amino, these latter nitrogen substituents optionally in the form of a basic nitrogen radical; - NHSO2-R or NHSO2NH-R or CO-R or COO-R or SO2-R or SO2NH-R where R corresponds to hydrogen, alkyl1 or (v) An O-aryl1, NH-aryl1, O-heteroaryl1 or NH group -heteroaryl1 (vi) Trifluoromethyl, O-alkyl1, carboxyl, cyano, nitro, formyl, hydroxy, NH-alkyl1, N (alkyl1) (alkyl1) and amino, these latter nitrogen substituents optionally in the form of a basic nitrogen radical, or (vii) NHSO2-R or NHSO2NH-R or CO-R or COO-R or SO2-R or SO2NH-R where R corresponds to hydrogen, alkyl1 or aryl. R8 is an alkyl, cycloalkyl, aryl or alkyloxy group; said groups are substituted or not by a halogen atom such as F, Cl, Br or I; And where the substituent X is: (i) Halogen selected from F, Cl, Br or L, or (ii) SR, SOR, where R is alkyl, aryl, CF3, F, CH2CF3, or (iii) OR, OTs, OMs, OTf, where R is alkyl or aryl. |
| priorityDate | 2006-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 110.