http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2351976-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39c68430bcb778feae2ad4e9640ad0ca |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-314 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3233 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0043 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2004-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9d3fd418c63eca607e0e9ebafffce5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eca647e92aa66095c963cd5a4f028d50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa818dd352a8dfc73ca2bf93845a3805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f312064f109f8afd5d0b062197569285 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88866f745b9e65cf72c3522167c0a6a7 |
| publicationDate | 2011-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2351976-T3 |
| titleOfInvention | COMPOSITIONS TO IMPROVE THE TRANSPORTATION AND ANTI-EFFECTIVE EFFECTIVENESS OF NUCLEIC ACID ANALOGS IN CELLS. |
| abstract | A method for improving the ability of a morpholino antisense oligomer to bind a target sequence in a nucleic acid, as evidenced by (i) a decrease in the expression of an encoded protein, relative to that observed with the oligomer unconjugated, when the binding of the antisense oligomer to its target sequence is effective to block a translation initiation codon of the encoded protein, or ii) an increase in the expression of an encoded protein, relative to that observed with the oligomer unconjugated, when the binding of the antisense oligomer to its target sequence is effective to block an aberrant splice site in a pre-mRNA that encodes said protein when cut and spliced correctly, and where the antisense oligomer is composed of subunits of morpholino linked by phosphorus-containing junctions between the morpholino nitrogen of a subunit and an exocyclic carbon in the position 3 of the morpholino of an adjacent subunit, and having a substantially non-charged main chain and a base sequence directed to a target, said method comprising conjugation to the antisense oligomer of a carrier peptide consisting of 8 to 16 amino acid residues and containing one of the sequences (RRY) x or (RYR) x, where x = 2 to 4, and Y is a neutral amino acid of the formula -C (O) - (CH2) n-NH-, where n is of 2 to 7. |
| priorityDate | 2003-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 200.