http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2351585-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2007-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d44820278aafe7175f83eacd3c85ec2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29d5f2bc4609612748d3100d47eb9de4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a00cea5a8eecb2fe9a7950986246975 |
| publicationDate | 2011-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2351585-T3 |
| titleOfInvention | DERIVATIVES OF PIRROLOQUINOXALINONA AS ANTIBACTERIAL AGENTS. |
| abstract | A compound of formula (I) or one of its pharmaceutically acceptable salts, solvates and / or N-oxides: ** (See formula) ** in which: R1a is selected from hydrogen; halogen; cyano; (C1-6) alkyl; alkylthio (C1-6); trifluoromethyl; trifluoromethoxy; carboxy; hydroxy optionally substituted with (C1-6) alkyl or (C1-6) alkyl substituted with (C1-6) alkoxy; (C1-6) alkyl substituted with (C1-6) alkoxy; hydroxyalkyl (C1-6); an amino group optionally N-substituted with one or two (C 1-6) alkyl, formyl, C 1-6 alkylcarbonyl or C 1-6 alkylsulfonyl groups; or aminocarbonyl wherein the amino group is optionally substituted with (C1-4) alkyl; R2 is hydrogen or (C1-4) alkyl, or together with R6 form Y as defined below; A is a group (i): ** (See formula) ** in which: R3 is as defined for R1a or is oxo and n is 1 or 2; or A is a group (ii) ** (See formula) ** in which: W1, W2 and W3 are CR4R8 or W2 and W3 are CR4R8 and W1 represents a link between W3 and N; X is O, CR4R8 or NR6; an R4 is as defined for R1a and the remaining and R8 are hydrogen, or an R4 and R8 are together oxo and the remaining are hydrogen; R6 is hydrogen or (C1-6) alkyl; or together with R2 form Y; R7 is hydrogen; halogen; hydroxy optionally substituted with (C1-6) alkyl; or (C1-6) alkyl; Y is CR4R8CH2; CH2CR4R8; (C = O); CR4R8; CR4R8 (C = O); or (C = O) CR4R8; or when X is CR4R8, R8 and R7 together represent a link; U is selected from CO and CH2 and R5 is a bicyclic, carbocyclic or heterocyclic ring system, optionally substituted (B): ** (See formula) ** containing up to 4 heteroatoms in each ring, in which at least one of rings (a) and (b) are aromatic; X1 is C or N when it is part of an aromatic ring, or CR14 when it is part of a non-aromatic ring; X2 is N, NR13, O, S (O) x, CO or CR14 when it is part of an aromatic or non-aromatic ring, or it can also be CR14R15 when it is part of a non-aromatic ring; X3 and X5 are independently N or C; Y1 is a connecting group of 0 to 4 atoms, each of whose atoms is independently selected from N, NR13, O, S (O) x, CO and CR14 when it is part of an aromatic or non-aromatic ring, or it can also be CR14R15 when part of a non-aromatic ring; Y2 is a connecting group of 2 to 6 atoms, in which each atom of Y2 is independently selected from N, NR13, O, S (O) x, CO, CR14 when it is part of an aromatic or non-aromatic ring, or it can be also CR14R15 when it is part of a non-aromatic ring; each of R14 and R15 is independently selected from: H; alkylthio (C1-4); halogen; carboxy-C1-4 alkyl; (C1-4) alkyl; (C1-4) alkoxycarbonyl; (C1-4) alkylcarbonyl; (C1-4) alkoxy-(C1-4) alkyl; hydroxy; hydroxyalkyl (C1-4); (C1-4) alkoxy; nitro; cyano; carboxy; amino or aminocarbonyl optionally mono or disubstituted with (C1-4) alkyl; or R14 and R15 together may represent oxo; each R13 is independently H; trifluoromethyl; (C1-4) alkyl optionally substituted with hydroxy, (C1-6) alkoxy, (C1-6) alkylthio, halogen or trifluoromethyl; alkenyl (C2-4); (C1-4) alkoxycarbonyl; (C1-4) alkylcarbonyl; C 1-6 alkylsulfonyl; aminocarbonyl in which the amino group is optionally mono or disubstituted with (C1-4) alkyl; each x is independently 0, 1 or 2; and R9 is hydrogen or hydroxy. |
| priorityDate | 2006-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 369.