http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2351161-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0f4f8190960626ec922a1f03bcd4aba |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate | 2006-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60f95026d5b7b5645b664265fb2ee3ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_979e577f5da710277f1e8d13c1ef94e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8aad50b549e8a3b16fea2d877690d297 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29fd5577435bb078ef5a1dd54839642b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42c80fe9f7a9a2fbf44830cff7b883cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b183d8c700eee98a7fd4dbc057ce2bce |
| publicationDate | 2011-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2351161-T3 |
| titleOfInvention | AZOL-BASED PHOSPHODIESTERASE INHIBITORS. |
| abstract | Compound, which has the structure of formula I, ** Formula ** or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, stereoisomer, tautomer, racemate, polymorph or N-oxide thereof, wherein R1 and R6 are independently hydrogen , alkyl, alkenyl, alkynyl, (in) saturated cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl, (heteroaryl) alkyl or (heterocyclyl) alkyl, X is oxygen, sulfur or NRh, wherein Rh is hydrogen, alkyl, alkenyl, alkynyl, (in) saturated cycloalkyl, acyl, aryl, aralkyl, heteroaryl, heterocyclyl, (heteroaryl) alkyl, (heterocyclyl) alkyl, S (O) nRd, wherein Rd is alkyl, aryl, heterocyclyl or heteroaryl and n is an integer between 0-2, Y is no atom or is oxygen, sulfur, NRh, in which Rh is as defined above, X1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heteroaryl, heterocyclyl , (heteroaryl) alkyl, (heterocyclyl ) alkyl, Y1 is hydrogen, alkyl, alkenyl, alkynyl, nitro, cyano, halogen, ORh, SRh, NHRh, COOR ', COR', CONHR ', S (O) nRd or Y1 can be melted into a benzene ring if Y1 is aryl, heteroaryl or heterocyclyl, wherein Rh and Rd are as defined above and R 'is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl (in) saturated, aryl, aralkyl, heterocyclyl, heteroaryl, (heterocyclyl) alkyl or (heteroaryl) alkyl, j is an integer between 1 and 3, R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, nitro, cyano, amino, substituted amino, alkoxy, aryloxy, COR ', COOR' , aryl, aralkyl, heteroaryl, heterocyclyl, (heteroaryl) alkyl, (heterocyclyl) alkyl, (CH2) 1-4ORR '' ', C (= O) NRxRy, (CH2) mC (= O) Rz, where R 'is as defined above, R' '' is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl (in) saturated, aryl, aralkyl, heterocyclyl, heteroaryl, (heterocyclyl) alkyl, (heteroaryl ) alkyl or hydroxy, Rx and Ry are independently hydrogen, alkyl, alkenyl having three to six carbon atoms, alkynyl having three to six carbon atoms, (in) saturated cycloalkyl, aryl, aralkyl, heteroaryl, heterocyclyl, (heteroaryl) alkyl, or (heterocyclyl) alkyl, m is an integer between 0-2 and Rz is Rp or Rq, wherein Rp is a 4-12 membered (1-) saturated monocyclic or bicyclic ring containing 1-12 4 heteroatom or heteroatoms selected from N, O or S, wherein said ring may be attached to (CH2) mC (= O) through N, and Rq is a 4-12 membered monocyclic or bicyclic ring containing 0 -4 heteroatom or heteroatoms selected from N, O or S, wherein said ring may be attached to (CH2) mC (= O) through C, R4 is hydrogen, alkyl, halogen, hydroxy, cyano, carboxy, nitro , C (= O) NRxRy, in which Rx and Ry are as defined above, and R5 is hydrogen, alkyl, aryl, aralkyl, cycloalk (in) saturated, heteroaryl, heterocyclyl, (heteroaryl) alkyl, or (heterocyclyl) alkyl, wherein R2, R3, R4 or R5 are optionally substituted by a bond, represented, for example, by the compounds of formula X and formula XXII, in which R3 and R5, respectively, are substituted by the link ** Formula ** |
| priorityDate | 2005-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 371.