http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2350854-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2006-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_874c6572b055ae72d78c92394c79d4bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35810a81d6eca8a7e9cb6f52901fb43b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e8eb3ce76bf3b12a3f2ce93b5f7780c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8589172da547df82ff754a132a7cbba1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a50b34023d3a3a9b6fc4d68faf4fffd3 |
| publicationDate | 2011-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2350854-T3 |
| titleOfInvention | ASPARTIL PROTEASA INHIBITORS. |
| abstract | A compound having the structural formula or a stereoisomer, tautomer or pharmaceutically acceptable salt or solvate thereof, wherein W is -C (= O) -; U is a bond, -S (O) -, -S (O) 2-, -C (O) -, - (C (R 6) (R 7)) - (C (R 6) (R 7) ) - or - (C (R 6) (R 7)) -; R is 1-5 substituents independently selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl, heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylheteroaryl, heterocycloalkenylheteroaryl, -NO2, halo, HO-alkoxyalkyl, -CF 3, -CN, alkyl-CN, -C (O) R 30, -C (O) OH, -C (O) OR 30, -C (O) NHR 31, -C (O) NH2, -C (O) NH2 C ( O) N (alkyl) 2, -C (O) N (alkyl) (aryl), -C (O) N (alkyl) (heteroaryl), -SR 30, -S (O) R 31, S (O) 2R 31, -S (O) NH2, -S (O) NH (alkyl), - S (O) N (alkyl) (alkyl), -S (O) NH (aryl), S (O) 2NH2, -S (O) 2NHR 30, -S (O) 2NH (heterocycloalkyl), -S (O ) 2N (alkyl) 2, S (O) 2N (alkyl) (aryl), -OCF3, -OH, -OR 31, -O-heterocycloalkyl, -O-cycloalkylalkyl, -O heterocycloalkylalkyl, -NH2, -NHR 31, -N (alkyl) 2, -N (arylalkyl) 2, -N (arylalkyl) (heteroarylalkyl), -NHC (O) R 31, -NHC (O) NH2, -NHC (O) NH (alkyl), NHC ( O) N (alkyl) (alkyl), -N (alkyl) C (O) NH (alkyl), -N (alkyl) C (O) N (alkyl) (alkyl), NHS (O) 2R 31, -NHS (O) 2 NH (alkyl), -NH S (O) 2N (alkyl) (alkyl), N (alkyl) S (O) 2NH (alkyl) and -N (alkyl) S (O) 2N (alkyl) ( I rent); R 5 is independently selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl , heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylheteroaryl, heterocycloalkenylheteroaryl, -OR 15, -CN, -C (O) R 8, -C (O) OR 9, S (O) R 10, -S (O) 2R 10, -C (O) N (R 11) (R 12), -S (O) N (R 11) (R 12) , -S (O) 2N (R 11) (R 12), -NO2, N = C (R 8) 2 and -N (R 11) (R 12); R 3 and R 4 are independently selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl, heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylheteroaryl, heterocycloalkenylheteroaryl, halo, -CH2-O-Si (R 9) (R 10) (R 19), -SH, -CN, -OR 9, -C (O) R 8, C (O) OR 9, -C (O) N (R 11) (R 12), -SR 19 , -S (O) N (R 11) (R 12), -S (O) 2N (R 11) (R 12), -N (R 11) (R 12 ), N (R 11) C (O) R 8, -N (R 11) S (O) R 10, -N (R 11) S (O) 2R 10, -N (R 11) C (O) N (R 12) (R 13), N (R 11) C (O) OR 9 and -C (= NOH) R 8; or R 3 and R 4, together with the carbon atoms to which they are attached, form a 3- to 7-membered cycloalkyl group optionally substituted with R 14, in which one, two or three ring carbons are optionally replaced by - O-, -C (O) -, -C (S) -, -S-, -S (O) -, -S (O) 2- or -N (R 5) -; or R 3, R 4, D and E together are where D or E is cycloalkenylene, heterocycloalkenylene, cycloalkylene, heterocycloalkylene, arylene or heteroarylene, M is -O-, -C (O) -, -S-, -CH2 -, -C (S) -, -S (O) -, -S (O) 2- or -N (R 5) -; in which one to five carbons in the ring are replaced by -O-, -C (O) -, -S-, -C (S) -, -S (O), -S (O) 2- or - N (R 5) -; q is 0, 1 or 2; or R 3, R 4 and D together are in which D is cycloalkenylene, heterocycloalkenylene, cycloalkylene, heterocycloalkylene, arylene or heteroarylene, in which one to five ring carbons are replaced by -O-, -C (O), -S-, -C (S) -, -S (O) -, -S (O) 2- or -N (R 5) -; with the following conditions that R 3 and R 4 cannot be combined to form said multicyclic groups in which M is -CH2-, -S-, -N (R 19) - or -O-; D and E are independently arylene or heteroarylene; and q is 0, 1 or 2 with the proviso that when q is 2, an M must be a carbon atom and when q is 2, M is optionally a double bond; and with the proviso that when there are at least two heteroatoms present, no adjacent oxygen and / or sulfur atom may be present in the ring systems described above; R 6 and R 7 are independently selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl, heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylheteroaryl, heterocycloalkenylheteroaryl, halo, -CH2-O-Si (R 9) (R 10) (R 19), -SH, -CN, -OR 9, C (O) R 8, -C (O) OR 9, -C (O) N (R 11) (R 12), -SR 19 , -S (O) N (R 11) (R 12), -S (O) 2N (R 11) (R 12), -N (R 11) (R 12) , -N (R 11) C (O) R 8, -N (R 11) S (O) R 10, -N (R 11) S (O) 2R 10, N (R 11) C (O) N (R 12) (R 13), -N (R 11) C (O) OR 9 and -C (= NOH) R 8; or R 6 and R 7, together with the carbon atoms to which they are attached, form a 3- to 7-membered cycloalkyl group optionally substituted with R 14, in which one, two or three ring carbons are optionally replaced by - O-, C (O) -, -C (S) -, -S-, -S (O) -, -S (O) 2- or -N (R 5) -; R 8 is independently selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl , heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylheteroaryl, heterocycloalkenylheteroaryl, -OR 15, -N (R 15) (R 16), -N (R 15) C (O) R 16, N (R 15) S (O) R 16, -N (R 15) S (O) 2R 16, -N (R 15) S (O) 2N (R 16 ) (R 17), N (R 15) S (O) N (R 16) (R 17), -N (R 15) C (O) N (R 16) (R 1 7) and -N (R 15) C (O) OR 16; R 9 is independently selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl, arylcycloalkenyl , heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenyryl, heterocycloalkenyl, heteroaryl, heteroalkyl heteroarylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenylcyclohenyl-heterocyclocarbonyl; cycloalkenylheteroaryl and R 10 is independently selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroarylheterocycloalkylalkyl, cycloalkyl, arylcycloalkyl, heteroarylcycloalkyl, heterocycloalkyl, arylheterocycloalkyl, heteroarylheterocycloalkyl, alkenyl, arylalkenyl, cycloalkenyl , arylcycloalkenyl, heteroarylcycloalkenyl, heterocycloalkenyl, arylheterocycloalkenyl, heteroarylheterocycloalkenyl, alkynyl, arylalkynyl, aryl, cycloalkylaryl, heterocycloalkylaryl, cycloalkenylaryl, heterocycloalkenylaryl, heteroaryl, cycloalkylheteroaryl, heterocycloalkylheteroaryl, cycloalkenylheteroaryl, heterocycloalkenylheteroaryl and -N (R 15) (R 16); R 11, R 12 and R 13 are independently selected from the group consisting of H, alkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylcycloalkylalkyl, heteroarylcycloalkylalkyl, arylheterocycloalkylalkyl, heteroaryl-heterocyclocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heteroaryl, alkyl |
| priorityDate | 2005-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 363.