abstract |
A di-PEGylated GLP-1 compound comprising an amino acid sequence of the formula: wherein Xaa8 is: D-Ala, Gly, Val, Leu, Ile, Ser or Thr; Xaa22 is: Gly, Glu, Asp or Lys; 10 Xaa33 is: Val or Ile; Xaa46 is: Cys or Cys-NH2; and wherein a PEG molecule is covalently linked to Cys45 and a PEG molecule is covalently linked to Cys46 or Cys46-NH |