http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2349999-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b3cdc77be3c946b845042535e5490b0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 |
| filingDate | 2006-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e9627ef87d9d4c878dc56c8b3a19d9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_526c3e60d9cba7ad7beb17c0e585b615 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_785b4e26ef61fd048c4649a2274b2002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_707c24159f509a64dbb9b4200dc529a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f39e40af0d8bf839e6cfd8c0c62285a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4735eeef9547cb8d2d781f05a197395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_631c6562239d81da7a219273d536f7ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b6796e482fc130a0a53d56ec5f51e65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f64381b75556923524083227016289da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e40cedaadc52f67ede978e8a8cb554fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cad4dee4c4b85a3fe4b381ca2722331a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f1cc06c1d58e73e4726de1dc9c4cea6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b88fcb0d5154b34a4b34cdfb418dc8f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_753e5d26bcd23040bef77fa0aacf06ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bc71bcef3cc0dabf8d8527f64bd2a3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27f96b3ed79ddb024c3cbdab8f3d3335 |
| publicationDate | 2011-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2349999-T3 |
| titleOfInvention | MACRÓLIDOS WITH ANTI-INFLAMMATORY ACTIVITY. |
| abstract | A compound of formula (I) ** Formula ** in which R1 is -OC (O) (CH2) nNR8R9, -O- (CH2) nNR8R9, -OC (O) N (R7) (CH2) nNR8R9, - OC (O) NN (CH2) n NR8R9, -O (CH2) nCN, -OC (O) (CH2) nN (CH2) nNR8R9, or - OC (O) CH = CH2 with the proviso that if R1 is - OC (O) CH = CH2, R3 cannot be methyl; R2 is a hydrogen atom or a hydroxyl group protecting group; R4 is a hydrogen atom, a C1-4 alkyl group or a C2-6 alkenyl group; R5 is a hydroxyl, methoxy, -OC (O) (CH2) nNR8R9, -O- (CH2) nNR8R9 or -O (CH2) nCN group; R6 is hydroxyl; or R5 and R6 taken together with the relevant atoms form a cyclic group having the following structure: ** Formula ** in which Y is a bivalent radical selected from the groups -CH2-, -CH (CN) -, -O -, -N (R7) - and -CH (SR7) -; R7 is hydrogen or C1-6 alkyl; each of R8 and R9 is independently hydrogen, C3-7 cycloalkyl or C1-18 alkyl, where C1-18 alkyl is: (i) interrupted or not with 1-3 bivalent radical groups selected from - O-, -S- and -N (R7) -; and / or (ii) unsubstituted or substituted with 1-3 groups selected from halogen, OH, NH2, N-alkylamino (C1-C6), N, N-di (C1-C6 alkyl) amino, CN, NO2, OCH3 , a non-aromatic C3-8 member ring that is saturated or unsaturated, a non-aromatic heterocyclic ring containing 2-6 carbon atoms that is saturated or unsaturated and containing 1-2 heteroatoms selected from oxygen, sulfur and nitrogen, alkylcarbonylalkoxy and alkoxycarbonylamino; or R8 and R9 taken together with the nitrogen to which they are attached form a non-aromatic heterocyclic ring containing 2-6 carbon atoms and which is: (iii) saturated or unsaturated and contains 0 or 1 additional heteroatoms selected from oxygen, sulfur and nitrogen; and / or (iv) unsubstituted or substituted with 1-2 groups selected from C1-5 alkanoyl and C1-6 alkyl, where C1-6 alkyl is uninterrupted or is interrupted with 1-3 bivalent radical groups selected from -O -, -S- and -N (R7) -, and / or which is unsubstituted or substituted with 1-2 groups selected from OH, NH2, a non-aromatic heterocyclic ring containing 2-6 carbon atoms and which is without substitute or are substituted with a group selected from C 1-4 alkyl, halo, NH 2, OH, SH, C 1-6 alkoxy and C 1-4 hydroxyalkyl, a C 3-7 cycloalkyl that is unsubstituted or substituted by a group selected from alkyl C1-4, halo, NH2, OH, SH, C1-6 alkoxy and C1-4 hydroxyalkyl; n is an integer from 1 to 8; and a) A is a bivalent radical selected from -C (O) -, -N (R7) CH2-, - CH2N (R7) -, -CH (OH) - and -C (= NOR7) -; and R3 is hydrogen; or b) A is a bivalent radical selected from -NHC (O) -, -C (O) NH-; and R3 is hydrogen or unsubstituted C1-4alkyl or C1-4alkyl substituted on the terminal carbon atom with a CN or NH2 group, or C1-5 alkanoyl; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2005-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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