| abstract |
An anti-CD20 antibody molecule fused with IL-2, comprising: (i) a modified heavy chain variable region polypeptide having the amino acid residue sequence of SEQ ID NO: 9, but including, at least one substitution of amino acid residues in said sequence, chosen from the group consisting of V12K, M20V, A68T, Q82E, T87R, S91T, D93V, and A114T, (ii) a modified, light chain variable region polypeptide, which has the amino acid residue sequence of SEQ ID NO: 11, but which includes, at a minimum, a substitution of amino acid residues in said sequence, chosen from the group consisting of L11I, S12T, A59S, S69T, L72M, R76S , and V77L, and (iii) a human IgG heavy chain constant region and a human light chain constant region. |