| abstract |
A compound of formula (I): wherein A 1 is N and A 2 is CR 7, or A 1 is CR 7 and A 2 is NY 1, Y 2 and Y 3 are each independently CH or N , Y 4 and Y 5 are, each independently, CR 8 or N, provided that, when one of Y 1, Y 2, Y 3, Y 4 and Y 5 is N, the others are not N, R 1 and R 2 are each independently hydrogen, halogen, C 1-6 alkyl, halo C 1-6 alkyl, or hydroxyalC 1-6 alkyl, R 3 and R 8 are each independently hydrogen, halogen, hydroxy, C 1-6 alkyl 6, 20 hydroxyC 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkoxyC 1-6 alkoxy, haloC 1-6 alkyl, C 1-6 alkylthio, C 1-6 alkyl sulfinyl or C 1-6 alkyl sulfonyl, R 4 is halogen, C1-6 alkyl, C3-6 cycloalkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 haloalkoxy, C1-6 hydroxyalkoxy, C1-6 alkoxy C1-6 alkyl, C1-6 alkoxy C1-6 alkoxy 6, C1-6 haloalkyl sulfonyl, C1-6 haloalkyl sulfinyl, C1-6 haloalkyl thio, [C1-6 alkyl] NH- or [C1-6 alkyl] 2N-; and 5, R 6 and R 7 are each independently hydrogen, halogen, C1-6 alkyl, C1-6 hydroxyalkyl or C1-6 alkoxy, or a pharmaceutically acceptable salt or solvate thereof. |