| abstract |
A compound of formula (I-A): including its salts, wherein R 1 is H or F; R 3 is - (Y) z-R 8; z is 0 or 1; Y is -CH = CH-; each of R 6 and R 7 are selected from H or alkyl; where z is 0, then R 8 is heterocyclyl, heterocyclyl substituted with one or more alkyl, -O (CH2) tCN, -CO2H, - (CH2) tCO2H, -O (CH2) tCO2H, -O (CH2) tOH, - O (CH2) tO (CH2) tOH or - O (CH2) tC (O) NH2; where z is 1, then R 8 is -CO2H or -CONH2; each t is independently from 1 to 8; and X is - (CH2) n-, where n is 0, 1 or 2 or O. |