| abstract |
A chemical entity that is a compound of Formula (I): where each of R 1-4 is independently H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, phenyl, -CF3, -OCF3, -CN , 10 halo, -NO2, -O-C1-C4 alkyl, -S-C1-C4 alkyl, -S (O) C1-C4 alkyl, -SO2 C1-C4 alkyl, -C (O) C1-C4 alkyl, - C (O) phenyl, -C (O) NR to R b, -CO2 C1-C4 alkyl, -CO2H, -C (O) NR to R b, or -NR to R b; where R a and R b are each independently H, C 1 -C 4 alkyl, or C 3 -C 7 cycloalkyl; one of X 1 and X 2 is N and the other is C-R c; where R c is H, methyl, hydroxyethyl, dimethylaminomethyl, ethyl, propyl, isopropyl, -CF3, cyclopropyl, or cyclobutyl; 20 n is 1 or 2; Z is N, CH, or C (C1-C4 alkyl); R 6 is H, C1-C6 alkyl, or monocyclic cycloalkyl; R 8 is H or C1-C4 alkyl, R 9 and R 10 are each independently H or C1-25 C4 alkyl, and R 11 is H or C1-C4 alkyl, a pharmaceutically acceptable salt of compound of Formula (I), or a hydrate of a compound of Formula (I). |