http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2347177-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff52e7d83fbaa644c922a9d38bb10bb7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2006-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3061f827fd96cf0384533460e4c13174 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d15cd1fe00bbacdac2815d5700f3da1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_653d0560231d94f1b3032d42e0aa6dc4 |
| publicationDate | 2010-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2347177-T3 |
| titleOfInvention | COMBINATION OF TRIAZINE DERIVATIVES AND INSULIN SENSITIZERS. |
| abstract | A pharmaceutical composition comprising, as active ingredient: # i) an insulin sensitizer # ii) a compound of the formula (I) in combination with one or more pharmaceutically acceptable excipients # ** (See formula) ** in which: # R1, R2, R3 and R4 are independently selected from the following groups: # H -, # (C2-C20) alkyl - optionally substituted with halogen, (C1-C5) alkyl - or (C1-C5) alkoxy -, # (C2-C20) alkenyl - optionally substituted with halogen, (C1-C5) alkyl - or (C1-C5) alkoxy - # (C2-C20) alkynyl - optionally substituted with halogen, (C1-C5) alkyl - or alkoxy ( C1-C5) - # (C3-C8) cycloalkyl - optionally substituted with (C1-C5) alkyl - or (C1-C5) alkoxy -, # heterocycloalkyl (C6-C8) - carrying one or more heteroatoms chosen from N, O and S and optionally substituted with (C1-C5) alkyl - or (C1-C5) alkoxy - # aryl (C6-C14) (C1-C20) alkyl - optionally substituted with amino, hydroxy, uncle, halogen, (C1 -C5) -, (C1-C5) alkoxy -, (C1-C5) alkylthio -, (C1-C5) alkylamino -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # aryl (C6-C14) - optionally substituted with amino, hydroxy, uncle, halogen , (C1-C5) alkyl, (C1-C5) alkoxy - (C1-C5) alkylthio -, (C1-C5) alkylamino -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy ) -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # heteroaryl (C1-C13) -, which carries one or more heteroatoms chosen from N, O and S and optionally substituted with amino, hydroxy, uncle, halogen, alkyl (C1 -C5) -, (C1-C5) alkoxy - (C1-C5) alkylthio -, (C1-C5) alkylamino -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxy ethyl, # R1 and R2, on the one hand, and R3 and R4, on the other, possibly form with the nitrogen atom a ring of n-members (n between 3 and 8) that optionally it contains one or more heteroatoms chosen from N, O and S and which is possibly substituted with one or more of the following groups: amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy - (C1-C5) alkylthio -, (C1-C5) alkylamino -, aryl (C6-C14) -, aryl (C6-C14) alkoxy (C1-C5) -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # R5 and R6 are independently selected from the following groups: # H -, # (C1-C20) alkyl - optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-C5) alkylthio -, (C1-C5) alkylamino -, (C6-C14) aryloxy -, (C6-C14) alkoxy ( C1-C5) -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # (C2-C20) alkenyl - optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy - , (C1-C5) alkylthio -, (C1-C5) alkylamino -, C6-C14 aryloxy -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # (C2-C20) alkynyl - optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-C5) alkylthio -, (C1-C5) alkylamino -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy - , cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, #cycloalkyl (C3-C8) - optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-) alkyl C5) -, (C1-C5) alkylamino -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxyethyl, # heterocycloalkyl (C3-C8) ) - carrying one or more heteroatoms chosen from N, O and S and optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-C5) alkylthio - , (C1-C5) alkylamino -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # aryl (C6-C14) - optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-C5) alkylthio -, (C1-C5) alkylamino -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxy ethyl, # heteroaryl (C1-C13) - carrying one or more heteroatoms chosen from N, O and S and optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-C5) alkylthio -, (C1-C5) alkylamino),, (C6) aryloxy -C14) -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # aryl (C6-C14) (C1-C5) alkyl - optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-C5) alkylthio -, (C1-C5) alkylamino -, aryloxy (C6-C14) -, aryl (C6-C14) (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxy ethyl, # R5 and R6 possibly form with the carbon atom to which a ring of m members (m between 3 and 8) is attached which optionally contains one or more heteroatoms chosen from N, O and S and possibly substituted by amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-C5) alkylthio -, (C1-alkylamino) -C5) -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # or possibly form with the carbon atom a C10-C30 polycyclic moiety optionally substituted with amino, hydroxy, uncle, halogen, (C1-C5) alkyl -, (C1-C5) alkoxy -, (C1-C5) alkylthio -, (C1-C5) alkylamino ) -, (C6-C14) aryloxy -, (C6-C14) aryl (C1-C5) alkoxy -, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, # R5 and R6 together also possibly represent the group = O or = S , the nitrogen atom of a heterocycloalkyl group or heteroaryl group that is possibly substituted with a (C1-C5) alkyl group, - (C3-C8) cycloalkyl -, aryl (C6-C14) -, aryl (C6-C14) alkyl (C1-C5) - or acyl (C1-C6) -, # and also racemic forms, tautomers, enantiomers, diastereoisomers, epimers and polymorphs and mixtures thereof, and pharmaceutically acceptable salts thereof. |
| priorityDate | 2006-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 220.