| abstract |
A compound of formula I ** (See formula) ** where X is -N = o = CH-; R1 is biphenyl, 4-phenoxy-phenyl or 4- (phenyl-C1-4alkoxy) -phenyl, wherein in each case at least one of the phenyl groups is monosubstituted with a halo-C1-4alkyl; R2 is C1-4alkyl optionally substituted with halogen, OH, NH2, C1-4alkoxy or C1-4alkylcarbonyloxy; Not me; OH; C1-4alkoxy; NH-OH; carboxy; sulfamoyl; carbamoyl; or HN-CO-C1-4alkyl; or R2 is R3-R4-COOH or R3-R4-CONH2 wherein R3 is SO2-NH, SO2-N (C1-4alkyl), CO-NH, CON (C1-4alkyl), CH2-O, NH-CO, or N (C1-4alkyl) CO; and R4 is C1-6alkylene optionally interrupted by O, S or C = CH2 or phenylene or C3-6cycloalkylene; and ring A may be phenyl or pyridyl, each being further optionally substituted with halogen, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy or nitrile; or R2 is hydrogen with the proviso that ring A is 3-pyridyl; or a salt thereof. |