| abstract |
Albumin binding polypeptide comprising an albumin binding motif, where the motif consists of the amino acid sequence: GVSDX5YKX8X9I X11X12AX14TVEGVX20 ALX23X24X25I in which, each independently of the others, X5 is selected from Y and F; X8 is selected from N, R and S; X9 is selected from V, I, L, M, F and Y; X11 is selected from N, S, E and D; X12 is selected from R, K and N; X14 is selected from K and R; X20 is selected from D, N, Q, E, H, S, R and K; X23 is selected from K, I and T; X24 is selected from A, S, T, G, H, L and D; and X25 is selected from H, E and D; provided that the amino acid sequence is not GVSDYYKNLI NNAKTVEGVK ALIDEI; the albumin binding polypeptide binding to the albumin such that the KD value of the interaction is at most 1 x 10-9 M. |