http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2345792-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 |
| filingDate | 2007-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f39c06e9b9cf326eb6777b656c54ecc9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3260f7a229082a16ba33c93dfc60a01b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_440c53ae6abb2daf7766eb17052eb8a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a1f8dfb4b2010e0f5e70f088a8f179c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bdad27d9a6a23b520b501d04f1b00df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67bb9e2d8d5a5f97fb68b676a895d4be |
| publicationDate | 2010-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2345792-T3 |
| titleOfInvention | INHIBITORS OF 11-BETA-HYDROXIESTEROID DEHYDROGENASE 1. |
| abstract | A compound structurally represented by the formula: ** (See formula) ** in which R0 is ** (See formula) ** in which the dashed line represents the point of attachment to the position R0; in which Ra is -halogen; Rb is -H or halogen; R1 is -H, -halogen, -O-CH3 (optionally substituted with one to three halogens), or -CH3 (optionally substituted with one to three halogens); R2 is -H, -halogen, -O-CH3 (optionally substituted with one to three halogens), or -CH3 (optionally substituted with one to three halogens); R3 is -H or -halogen; R4 is -OH, -halogen, -CN, -C1-C4 alkyl (optionally substituted with one to three halogens), -O-C1-C6 alkyl (optionally substituted with one to three halogens), - SCF3, -O (O) (C1-C4) alkyl, -O-CH2-C (O) NH2, -C3-C8 cycloalkyl, -O-phenyl-C (O) O-(C1-C4) alkyl , -CH2-phenyl, -NHSO2-alkyl (C1-C4), -NHSO2-phenyl (R21) (R21), -alkyl (C1-C4) -C (O) N (R10) (R11), ** ( See formula) ** ** (See formula) ** in which the dashed line represents the point of attachment to position R4; R5 is -H, -halogen, -OH, -CN, -C1-C4 alkyl (optionally substituted with 1 to 3 halogens), -C (O) OH, -C (O) O-C1-alkyl C4), -C (O) -C1-C4 alkyl, -O-C1-C4 alkyl (optionally substituted with 1 to 3 halogens), -SO2-C1-C4 alkyl, -N (R8 ) (R8), -phenyl (R21) (R21), -C (O) -NH-cycloalkyl (C3-C6), ** (See formula) ** ** (See formula) ** or ** (See formula) ** in which the dashed line represents the point of attachment to the position indicated by R5; in which m is 1, 2 or 3; in which n is 0, 1 or 2, and in which when n is 0, then "(CH2) n" is a link; R6 is -H, -halogen, -CN, or-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens); R7 is -H, -halogen, or-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens); R8 is, independently at each occurrence, -H, -C1-C6 alkyl (optionally substituted with 1 to 3 halogens), -C (O) C1-C6 alkyl (optionally substituted with 1 to 3 halogens) , -C (O) -C3-C8-cycloalkyl, -S (O2) -C3-C8 -cycloalkyl or -S (O2) -C1-C3-alkyl (optionally substituted with 1 to 3 halogens); R9 is -H or -halogen; each of R10 and R11 is, independently, -H or-(C1-C4) alkyl, or R10 and R11 taken, together with the nitrogen to which they are attached, form piperidinyl, piperazinyl, or pyrrolidinyl; R20 is, independently at each occurrence, -H, or -C1-C3 alkyl (optionally substituted with 1 to 3 halogens); R21 is, independently at each occurrence, -H, -halogen, or -alkyl (C1-C3) (optionally substituted with 1 to 3 halogens), -CN, -C (O) -N (R22) (R22) ( wherein optionally the two occurrences of R22, together with the nitrogen to which they are attached, form azetidinyl, pyrrolidinyl, or piperidinyl); R22 is, independently at each occurrence, -H or -C1-C6 alkyl (optionally substituted with 1 to 3 halogens); and R23 is, independently at each occurrence, -H, -C1-C4 alkyl, or -C (O) O-C1-C4 alkyl, or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2006-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 641.