http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2345146-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-28 |
| filingDate | 2003-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08cd3e0ad02b5ef494120dc092d8042b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08266ff020c5f93a5007ebb870963807 |
| publicationDate | 2010-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2345146-T3 |
| titleOfInvention | INHIBITORS OF 17BETA-HYDROXIESTEROIDS DEHYDROGENASE TYPE 3 FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES. |
| abstract | A compound represented by the structural formula: or a pharmaceutically acceptable salt or solvate thereof, ** (See formula) ** in which: X is CH or N; Z is O or N (R8); R1 and R2 are the same or different, each independently being selected from the group consisting of aryl, heteroaryl, aralkyl and heteroaralkyl, wherein each of said aryl, heteroaryl, aralkyl and heteroaralkyl may be unsubstituted or optionally substituted independently with one or more moieties that may be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl, heterocyclyl, CF3, CN, -OCF3, -OR6, -C (O) R7, -NR6R7, -C (O) OR6, -C (O) NR6R7, -SR6, -S (O2) R7, -S (O2) NR6R7, -N (R6) S (O2) R7, -N (R6) C (O) R7 and -N (R6) C (O) NR6R7; R3 is H or -OR6, with the proviso that when X is N, R3 is not -OR6; R4 is selected from the group consisting of H, alkyl, aryl, cycloalkyl, aralkyl, heteroaryl, heteroaralkyl and heterocyclyl; m is a number from 0 to 4, and when m is greater than 1, the R4 groups can be the same or different and are independently selected; R5 is -C (O) R7 or -S (O2) R7; R6 is selected from the group consisting of H, alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl and heterocyclyl, wherein each of said alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl and heterocyclyl may be unsubstituted or optionally independently substituted with one or more moieties that may be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, cycloalkyl, CF3, OCF3, CN, -OR7, -NHR7, -N (R7) 2, -CN2OR7, -C (O) R7, -C (O) OR7, -C (O) NHR7, -C (O) N (R7) 2, -SR7, -S (O2) R7, -S ( O2) NHR7, -S (O2) N (R7) 2, -N (R7) S (O2) R7, -N (R7) C (O) R7, -N (R7) C (O) NHR7 and -N (R7) C (O) N (R7) 2; and R7 is selected from the group consisting of alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, -OR6, -NH R6, and -N (R6) 2, wherein each of said alkyl, heteroaralkyl, aryl, heteroaryl and aralkyl may be unsubstituted or optionally substituted independently with one or more moieties that may be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, cycloalkyl, CF3, OCF3, CN, -OR6, -NHR6 , -N (R6) 2, -CH2OR6, -C (O) OR6, -C (O) NHR6, -C (O) N (R6) 2, -SR6, -S (O2) R6, -S (O2 ) NHR6, -S (O2) N (R6) 2, -N (R6) S (O2) R8, -N (R6) C (O) R6, -N (R7) C (O) NHR8 and -N ( R7) C (O) N (R7) 2, additionally in which the two R6 groups or the two R7 groups in the -N (R6) 2 and -N (R7) 2 moieties can respectively be the same or different and independently selected , and additionally in which neither of the two adjacent alkyl substituents in an aryl or heteroaryl can be joined together to form a methylenedioxy or ethylene group nioxy, where Alkyl means an aliphatic hydrocarbon group, which can be linear or branched and comprising from about 1 to about 20 atoms in the chain; Aryl means a monocyclic or multicyclic aromatic ring system comprising from about 6 to about 14 carbon atoms; "Heteroaryl" means a monocyclic or multicyclic aromatic ring system comprising from about 5 to about 14 ring atoms, in which one or more of the atoms in the ring is a non-carbon element; Aralkyl means an aryl-alkyl- group in which aryl and alkyl are as defined above; Cycloalkyl means a mono or multicyclic non-aromatic ring system comprising from about 3 to about 10 carbon atoms; Heterocyclyl means a monocyclic or multicyclic saturated non-aromatic ring system comprising from 3 to 10 carbon atoms, wherein one or more of the atoms in the ring system is a non-carbon element; Heteroaralkyl means a heteroaryl-alkyl- group, in which the heteroaryl and the alkyl are as defined above; Heterocyclylalkyl means a heterocyclyl-alkyl group, in which the heterocyclyl and alkyl are as defined above. |
| priorityDate | 2002-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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