| abstract |
A pharmaceutical composition comprising an amide anesthetic encapsulated in a multivesicular liposome, said multivesicular amide anesthetic liposome; at least one acid selected from the group consisting of a diprotic mineral acid, a triprotic mineral acid and a polyhydroxy carboxylate or combinations thereof; a lipid component comprising at least one amphipathic lipid and at least one neutral lipid lacking a hydrophilic head group; and, optionally, a cholesterol and / or a vegetable sterol. |