| abstract |
A compound of formula (I): ** (See formula) ** in which: X is O, either S, NH or CH2 and Y is CH2 or a direct bond, or Y is O, S or NH and X is CH2; and R is a 3-12 membered cycloalkyl, 2,3-dihydrobenzofuranyl, aryl or heteroaryl, where any ring may be optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, nitro, amino, hydroxycarbonyl, (C1-C6) alkyl, (C1-C6) alkenyl, (C1-C6) alkynyl, (C1-C6) alkoxy, (C1-C6) hydroxyalkyl, (C1-C6) alkoxy (C1-C6) alkyl, perfluoroalkyl ( C1-C6), perfluoro-C1-C6 alkoxy, (C1-C6) alkyl, amino (C1-C6) alkyl, amino (C1-C6) alkyl, (C1-C6) alkyl (C1-C6) alkyl, dialkyl (C1-C6) aminoalkyl (C1-C6), acyl (C1-C6), acyloxy (C1-C6), acyloxy (C1-C6) alkyl (C1-C6), acyl (C1-C6) amino, alkyl ( C1-C6) thio, (C1-C6) alkyl thiocarbonyl, (C1-C6) alkyl thioxo, (C1-C6) alkoxycarbonyl, (C1-C6) alkyl sulfonyl, (C1-C6) alkyl sulfonylamino, aminosulfonyl, alkyl ( C1-C6) aminosulfonyl, dialkyl (C1-C6) aminosulfonyl, 3-8 membered cycloalkyl, 4-8 membered heterocycloalkyl, phenyl and monocyclic heteroaryl; or its pharmaceutically acceptable salt or solvate, for use in the treatment of pain. |