| abstract |
Use of a nucleotide sequence that encodes gag and pol retroviral proteins capable of assembling a retroviral vector genome in a retroviral particle in a producing cell to generate a defective replication retrovirus in a target cell, in which the nucleotide sequence is optimized in its codons for expression in the producing cell, and wherein the nucleotide sequence comprises the sequence shown in SEQ ID NO: 16. |