| abstract |
An anti-CD22 antibody with a variable light chain (VL) having the sequence of the VL chain of the RFB4 antibody of Figure 1 and a variable heavy chain (VH) having the sequence of the VH chain of the RFB4 antibody of Figure 1, provided that the SSY residues of positions 104, 105 and 106 of CDR3 of the VH chain of said anti-CD22 antibody are replaced by an amino acid sequence selected from the group consisting of THW, YNW, TTW and STY. |