http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2341008-T3

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filingDate 2004-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2010-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6b7b94c8d4383a99b0511eda6cf9569
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publicationDate 2010-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2341008-T3
titleOfInvention PROCEDURE FOR DRIVING BICALUTAMIDE AND PROCEDURE FOR PURIFICATION OF INTERMEDIATE PRODUCTS FOR THE SAME.
abstract Process for producing bicalutamide of formula (4): ** (See formula) ** comprising Step A, which comprises the reaction of compound (1) of formula (1) ** (See formula) ** with peroxycarboxylic acid, to obtain the compound (2) of formula (2); ** (See formula) ** Step B, which comprises the reaction of said compound (2) with 4-fluorothiophenol to obtain crude crystals of the compound (3) of formula (3); ** (See formula) ** comprising 0.06 to 0.05% of 4 '' - cyano-3- (4-fluorophenylthio) -2-methyl-3 '' - trifluoromethylpropionanilide, dissolve the crude crystals in a solvent, and crystallize to obtain purified crystals of the compound (3), and step C, which comprises the reaction of the compound (3) and of the percarboxylic acid to obtain bicalutamide.
priorityDate 2003-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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