http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2340696-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fda45c540f11df3a7fe71d54a70562a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4995 |
| filingDate | 2005-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_592c722796f0508edbaca4780dab1e51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fb0683e60e4936d4a2b08a163653842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e89770cb5de3cad50a72b584d4122c95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46726b1c0e469e7b3edc3890e5e1e5da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27a41330fc592a85b8ee111570d4bd3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4a6398912f727799393d4f9ae1ca564 |
| publicationDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2340696-T3 |
| titleOfInvention | BICYCLONONE DERIVATIVES AS RENINA INHIBITORS. |
| abstract | A compound selected from the group consisting of biciclononene compounds of formula (I) ** (See formula) ** X represents -NH-, -N (L) -, -O-, or -S-; W represents a five-membered heteroaryl containing one or two heteroatoms independently selected from nitrogen, oxygen and sulfur, said heteroaryl radical being optionally mono-substituted with C1-7 alkyl; V represents -CH2CH2-O-, -CH2CH2CH2-O-, -O-CH2CH2-O-, -O-CH2CH2CH2-O-, -CH2-O-CH2CH2-O-, -O-CH2CH2-O-CH2-, u -O-CH2CH2CH2-O-CH2-; U represents unsubstituted aryl; mono-, di-, tri- or tetra-substituted aryl, wherein the substituents are independently selected from C1-7 alkyl, C1-7 alkoxy, -CF3, -OCF3, halogen and C1-7 hydroxyalkyl; or five-membered heteroaryl containing two heteroatoms independently selected from nitrogen, oxygen and sulfur, said heteroaryl radical being optionally mono-, di- or tri-substituted, in which the substituents are independently selected from C1-7 alkyl, C1- alkoxy 7, -CF3, -OCF3 and halogen; T represents -CONR1- or -CH2CONR1-; Q represents methylene; M represents unsubstituted aryl; mono-di- or tri-substituted aryl, wherein the substituents are independently selected from C1-7 alkyl, C1-7 alkoxy, -OCF3, -CF3, C1-7 hydroxyalkyl, and halogen; or mono- or di-substituted pyridinyl, wherein the substituents are independently selected from halogen, C1-7 alkyl, -OCF3, -CF3 and C1-7 alkoxy; with the proviso that the halogen substituents are not in the 2 or 6 position of the pyridinyl ring; L represents -R3, -COR3, -COOR3, -CONR2R3, -SO2R3, or -SO2NR2R3; R1 and R1 '' independently represent C1-7 alkyl or cycloalkyl; R2 and R2 '' independently represent hydrogen, C1-7 alkyl, C2-7 alkenyl, cycloalkyl, or cycloalkyl-C1-7 alkyl; R3 represents C1-7 alkyl, cycloalkyl, or cycloalkyl-C1-7 alkyl, these groups may be unsubstituted or mono-, di- or tri-substituted, in which the substituents are independently selected from hydroxy, -NH2, -OCOR2 , -COOR2, -SO3H, -SO2CH3, C1-7 alkoxy, cyano, -CONR2R2 '', -NH (NH) NH2, -NR1R1 '', tetrazolyl and C1-7 alkyl, with the condition that a carbon atom be bound at most to a heteroatom in case this carbon atom has sp3 hybridization; and optically pure enantiomers, mixtures of enantiomers such as racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates, and meso-forms, as well as salts and complexes with solvents of such compounds, and morphological forms. |
| priorityDate | 2004-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 421.