http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2339980-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34bd4e87ecbca17f16d460ca394e60f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 |
| filingDate | 2006-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_979c91351f2697572e55df1e8612c535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c91a07b2123c84bb2d80e154874900c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76e47c88a080d34bce1968f4ff6510ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_601251d998c7146bfd16a21be3f6eaf5 |
| publicationDate | 2010-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2339980-T3 |
| titleOfInvention | SUBSTITUTED TIAZOLS AND ITS USE FOR THE PRODUCTION OF MEDICINES. |
| abstract | Substituted thiazoles of the general formula I, ** (See formula) ** where R1 and R2 represent in each case, independently of each other, H; F; Cl; Br; I; -NO2; -CN; -NH2; -OH; -SH; -C (= O) -OH; -C (= O) -H; -NH-C (= O) -H; -NH-R55; -NR56R57; -C (= O) -R58; -C (= O) -O-R59; -O-C (= O) -R60; -NH-C (= O) -R61; -NR62-C (= O) -R63; -C (= O) -NH2; -C (= O) -NH-R64; -C (= O) -NR65R66; -O-R67; -S-R68; -S (= O) -R69; -S (= O) 2-R70; -NH-C (= O) -NH-R71; -NH-C (= S) -NH-R72; -NH-S (= O) 2-R73; -NR74-S (= O) 2-R75; alkyl, alkenyl or alkynyl substituted at least simply or unsubstituted; heteroalkyl, heteroalkenyl or heteroalkynyl substituted at least simply or unsubstituted; cycloalkyl or cycloalkenyl substituted at least simply or unsubstituted; heterocycloalkyl or heterocycloalkenyl substituted at least simply or unsubstituted; - (alkylene) cycloalkyl, - (alkenylene) cycloalkyl, - (alkynylene) cycloalkyl, - (alkylene) cycloalkenyl, - (alkenylene) cycloalkenyl or - (alkynylene) cycloalkenyl substituted at least simply or unsubstituted; - (heteroalkylene) cycloalkyl, - (heteroalkenylene) cycloalkyl, - (heteroalkylene) cycloalkenyl or - (heteroalkenylene) cycloalkenyl substituted at least simply or unsubstituted; - (alkylene) heterocycloalkyl, - (alkenylene) heterocycloalkyl, - (alkynylene) heterocycloalkyl, - (alkylene) heterocycloalkenyl, - (alkenylene) heterocycloalkenyl or - at least simply or unsubstituted; - (heteroalkylene) heterocycloalkyl, - (heteroalkenylene) heterocycloalkyl, - (heteroalkylene) heterocycloalkenyl or - (heteroalkenylene) -heterocycloalkenyl substituted at least simply or unsubstituted; aryl substituted at least simply or unsubstituted; heteroaryl substituted at least simply or unsubstituted; - (alkylene) aryl, - (alkenylene) aryl, - (alkynylene) aryl, - (heteroalkylene) aryl or - (heteroalkenylene) aryl substituted at least simply or unsubstituted; or - (alkylene) heteroaryl, - (alkenylene) heteroaryl, - (alkynylene) heteroaryl, - (heteroalkylene) heteroaryl or - (heteroalkenylene) heteroaryl substituted at least simply or unsubstituted; or R1 and R2, together with the carbon atoms that bind them, constitute a phenylene group substituted at least simply or unsubstituted; R3, R8 and R54 represent in each case, independently of each other, H; -C (= O) -R58; -C (= O) -O-R59; -C (= O) -NH2; -C (= O) -NH-R64; -C (= O) -NR65R66; -S (= O) -R69; -S (= O) 2-R70; substituted or unsubstituted alkyl, alkenyl or alkynyl; substituted or unsubstituted heteroalkyl, heteroalkenyl or heteroalkynyl; substituted or unsubstituted cycloalkyl or cycloalkenyl; substituted or unsubstituted heterocycloalkyl or heterocycloalkenyl; - (alkylene) cycloalkyl, - (alkenylene) cycloalkyl, - (alkynylene) cycloalkyl, - (alkylene) cycloalkenyl, - (alkenylene) cycloalkenyl or - (alkynylene) substituted or unsubstituted cycloalkenyl; - (heteroalkylene) cycloalkyl, - (heteroalkenylene) cycloalkyl, - (heteroalkylene) cycloalkenyl or - (heteroalkenylene) substituted or unsubstituted cycloalkenyl; - (alkylene) -heterocycloalkyl, - (alkenylene) heterocycloalkyl, - (alkynylene) -heterocycloalkyl, - (alkylene) heterocycloalkenyl, - (alkenylene) -heterocycloalkenyl or - (alkynylene) substituted or unsubstituted heterocycloalkenyl; - (heteroalkylene) heterocycloalkyl, - (heteroalkenylene) -heterocycloalkyl, - (heteroalkylene) heterocycloalkenyl or - (heteroalkenylene) heterocycloalkenyl substituted or unsubstituted; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; - (alkylene) aryl, - (alkenylene) aryl, - (alkynylene) aryl, - (heteroalkylene) aryl or - (heteroalkenylene) substituted or unsubstituted aryl; or - (alkylene) heteroaryl, - (alkenylene) heteroaryl, - (alkynylene) heteroaryl, - (heteroalkylene) -heteroaryl or - (heteroalkenylene) heteroaryl substituted or unsubstituted; R4, R5, R6, R7, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, R42, R43, R44, R45, R46, R47, R48, R49, R50, R51, R52 and R53 represent in each case, independently of each other, H; F; Cl; Br; I; -NO2; -CN; -NH2; -OH; -SH; -C (= O) -OH; -C (= O) -H; -NH-C (= O) -H; -NH-R55; -NR56R57; -C (= O) -R58; -C (= O) -O-R59; -O-C (= O) -R60, -NH-C (= O) -R61; -NR62-C (= O) -R63; C (= O) -NH2; -C (= O) -NH-R64; -C (= O) -NR65R66; -O-R67; -S-R68; -S (= O) -R69; -S (= O) 2-R70; -NH-C (= O) -NH-R71; -NH-C (= S) -NH-R72; -NH-S (= O) 2-R73; -NR74-S (= O) 2-R75; substituted or unsubstituted alkyl, alkenyl or alkynyl; substituted or unsubstituted heteroalkyl, heteroalkenyl or heteroalkynyl; substituted or unsubstituted cycloalkyl or cycloalkenyl; substituted or unsubstituted heterocycloalkyl or heterocycloalkenyl; - (alkylene) cycloalkyl, - (alkenylene) cycloalkyl, - (alkynylene) cycloalkyl, - (alkylene) cycloalkenyl, - (alkenylene) cycloalkenyl or - (alkynylene) substituted or unsubstituted cycloalkenyl; - (heteroalkylene) cycloalkyl, - (heteroalkenylene) cycloalkyl, - (heteroalkylene) cycloalkenyl or - (heteroalkenylene) substituted or unsubstituted cycloalkenyl; - (alkylene) -heterocycloalkyl, - (alkenylene) heterocycloalkyl, - (alkynylene) -heterocycloalkyl, - (alkylene) heterocycloalkenyl, - (alkenylene) -heterocycloalkenyl or - (alkynylene) substituted or unsubstituted heterocycloalkenyl; - (heteroalkylene) heterocycloalkyl, - (heteroalkenylene) -heterocycloalkyl, - (heteroalkylene) heterocycloalkenyl or - (heteroalkenylene) heterocycloalkenyl substituted or unsubstituted; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; - (alkylene) -aryl, - (alkenylene) aryl, - (alkynylene) aryl, - (heteroalkylene) aryl or - (heteroalkenylene) substituted or unsubstituted aryl; or - (alkylene) heteroaryl, - (alkenylene) heteroaryl, - (alkynylene) heteroaryl, - (heteroalkylene) -heteroaryl or - (heteroalkenylene) heteroaryl substituted or unsubstituted; or R4 and R5, or R6 and R7, or R10 and R11, or R12 and R13, or R14 and R15, or R16 and R17, or R18 and R19, or R20 and R21, or R22 and R23, or R24 and R25, or R26 and R27, or R28 and R29, or R30 and R31, or R32 and R33, or R34 and R35, or R36 and R37, or R38 and R39, or R40 and R41, or R42 and R43, or R44 and R45, or R46 and R41, or R48 and R49, or R50 and R51, or R52 and R53, independently of each other, together represent in each case a group selected from the group consisting of an oxo group (= O) and a thioxo group ( = S); or R3 and R4, together with the group -N-CR5 that unites them, constitute a group of general formula A, ** (See formula) ** or R6 and R8, together with the group -N-CR7 that unites them, they constitute a group of general formula B, ** (See formula) ** "m" and "q" represent in each case 1, 2, 3, 4 or 5; "n" and "p" in each case represent 0, 1, 2, 3 or 4; "k" and "o" in each case represent 0 or 1; being the sum of "m", "n" and "k", or the sum of "p", "q" and "o", in each case equal to 1, 2, 3, 4, 5 or 6; or R3 and R6, together with the group -N-CR4R5-CR7 that unites them, constitute a group of general formula C, ** (See formula) ** or R4 and R8, together with the group -CR5-CR6R7-N which binds them together, constitute a group of general formula D, ** (See formula) ** "r" and "u" in each case represent 1, 2, 3 or 4; "t" and "w" in each case represent 0, 1, 2 or 3; "s" and "v" in each case represent 0 or 1; being the sum of "r", "s" and "t", or the sum of "u", "v" and "w", in each case equal to 1, 2, 3, 4 or 5; or R3 and R8, together with the group -N-CR4R5-CR6R7-N that unites them, constitute a group of general formula E, ** (See formula) ** "x" e "and" represent in each case 0 or one; "z" represents 0 or 1; the sum of "x", "y" and "z" being equal to 3 or 4; or R4 and R6, together with the group -CR5-CR7 that unites them, constitute a group of general formula F, ** (See formula) ** "aa" and "cc" represent in each case, independently of each other, 1 , 2, 3, 4 or 5; "bb" represents 0 or 1; the sum of "aa", "bb" and "cc" being equal to 1, 2, 3, 4, 5 or 6; or R3 and R4, together with the group -N-CR5 that unites them, and R6 and R8, together with the group -N-CR7 that unites them, constitute a group of general formula G, ** (See formula) ** "dd" and "ee" represent in each case, independently of each other, 1, 2, 3 or 4; or R3 and R6, together with the group -N-CR4CR5-CR7 that unites them, and R4 and R8, together with the group -CR5-CR6R7-N that unites them, constitute a group of general formula H, ** (See formula) ** "ff" and "gg" represent in each case, independently of each other, 1, 2 or 3; or R3 and R8, together with the group -N-CR4R5-CR6R7-N that unites them, and R4 and R6, together with the group -CR5-CR7 that unites them, constitute a group of general formula K, ** (See formula) ** "hh" represents 1, 2, 3 or 4; "kk" represents 1, 2, 3, 4, 5 or 6; or R3 and R8, together with the group -N-CR4R5-CR6R7-N that binds them together, constitute a bicyclic group of general formula L, ** (See formula) ** "mm" represents 1, 2 or 3; "nn" represents 1 or 2; or R3 and R8, together with the group -N-CR4R5-CR6R7-N that unites them, constitute a bicyclic group of general formula M, ** (See formula) ** "pp" represents 1 or 2; "qq" represents 1, 2 or 3; X represents O, S or N-R54; R9 represents H; F; Cl; Br; I; -CN; -C (= O) -OH; -C (= O) -H; -C (= O) -R58; -C (= O) -O-R59; C (= O) -NH2; -C (= O) -NH-R64; -C (= O) -NR65R66; substituted or unsubstituted alkyl, alkenyl or alkynyl; substituted or unsubstituted heteroalkyl, heteroalkenyl or heteroalkynyl; substituted or unsubstituted cycloalkyl or cycloalkenyl; substituted or unsubstituted heterocycloalkyl or heterocycloalkenyl; - (alkylene) cycloalkyl, - (alkenylene) cycloalkyl, - (alkynylene) cycloalkyl, - (alkylene) cycloalkenyl, - (alkenylene) -cycloalkenyl or - (alkynylene) substituted or unsubstituted cycloalkenyl; - (heteroalkylene) cycloalkyl, - (heteroalkenylene) cycloalkyl, - (heteroalkylene) cycloalkenyl or - (heteroalkenylene) substituted or unsubstituted cycloalkenyl; - (alkylene) heterocycloalkyl, - (alkenylene) -heterocycloalkyl, - (alkynylene) heterocycloalkyl, - (alkylene) -heterocycloalkenyl, - (alkenylene) heterocycloalkenyl or - (alkynylene) -heterocycloalkenyl; - (heteroalkylene) -heterocycloalkyl, - (heteroalkenylene) -heterocycloalkyl, - (hete |
| priorityDate | 2005-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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