http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2339756-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f384d3adb6a65c640b912fa2f22478a5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-38 |
| filingDate | 2002-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a4fd76949823bd4c9f7bf6ba96d6041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce481d4e255b26abb19655d14cdd1c81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_728c0d557dd0ca1db48962f38cba4ae6 |
| publicationDate | 2010-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2339756-T3 |
| titleOfInvention | IMPROVED PROCEDURE FOR THE PREPARATION OF AMYNOMETHYLCILLOCANACETIC ACIDS. |
| abstract | Process for the preparation of gabapentin of formula 1 ** (See formula) ** comprising: (i) preparing an aqueous solution of gabapentin hydrochloride in water with a proportion of a part by weight of gabapentin hydrochloride with respect to 0, 5-3 parts by weight of water; (ii) preparing an aqueous solution of sodium or potassium hydroxide in a concentration of the order of 40-50% w / w; (iii) add 0.08 to 0.3 parts by weight of the solution obtained in phase (ii) to 1.5-4 parts by weight of the solution obtained in phase (i) at a temperature in a range from 0 to 20 degrees C in the form of a resulting solution; (iv) gradually heat the resulting solution to a temperature in a range of 50-90 degrees C; (v) gradually cooling the resulting solution to a temperature in a range of 0 to 15 degrees C to obtain a precipitate; (vi) let the precipitate stand for a period of time between 0.5 and 8 hours at a temperature in the range of 0 to 15 degrees C; (vii) separate the precipitate from its mother liquor by conventional methods; and (viii) recrystallize the precipitate from a mixture of isopropyl alcohol (IPA), methanol and water to obtain gabapentin with a purity greater than 99.5% and another mother liquor. |
| priorityDate | 2002-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.