| abstract |
Transdermal Therapeutic System (TTS) with high safety with respect to an unforeseen administration of an active substance overdose, comprising a support layer impermeable to the active substance, a layer containing active substance, in which the active substance is fentanyl, sufentanil, carfentanil, lofentanil and / or alfentanil and / or a salt of fentanyl, sufentanil, carfentanil, lofentanil and / or alfentanil, and in which the layer containing active substance comprises a polymer or a mixture of polymers with microdeposites dispersed therein , a membrane layer that follows on the side of the skin, which is constituted by an ethylene-vinyl acetate copolymer or a microporous sheet based on polyethylene or polypropylene, if necessary an adhesive layer that is then connected, and finally a protective layer that must be removed before use. |