| abstract |
A compound of formula: ** (See formula) ** in which, R1 represents hydrogen, hydroxy, cyano, halo, nitro, (C1-C4) alkyl, haloalkyl (C1-C4), haloalkoxy (C1-C4), SCH3, C (= S) NH2, CH = NOCH3, CH = NOCH2CH3, C (NOCH3) CH3, C (NOCH2CH3) CH3, CH = NOH, COR1a, OR1b, SO2R1c, NHCOR1d, or a 5- to 6-membered heteroaryl group optionally substituted with 1 or 2 substituents selected from the group consisting of amino, cyano, (C1-C4) alkyl, alkoxy (C1-C4), halo, haloalkyl (C1-C4), or haloalkoxy (C1-C4); R1a represents hydrogen, amino, hydroxy, (C1-C4) alkyl, (C1-C4) alkoxy, or (C1-C4) haloalkyl; R1b represents (C1-C4) alkyl, cyclopropyl, or cyclopropylmethyl; R1c represents amino or (C1-C4) alkyl; R1d represents (C1-C4) alkoxy; R2 represents hydrogen, halo, (C1-C4) alkyl, or (C1-C4) alkoxy, or R1 and R2 together form a group of formula ** (See formula) ** R3 represents NHCOR3a or NHSO2R3b; R3a and R3b each independently represents each time (C1-C6) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, cyclopropyl, cyclobutyl, NH-(C1-C4) alkylamine, N, N-dialkylamine (C1-C6) or N (CH3) OCH3; and R4 represents a phenyl group optionally substituted with 1 or 2 substituents selected from the group consisting of amino, hydroxy, cyano, halo, nitro, (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkyl, haloalkoxy (C1-C4), NH-alkylamine (C1-C4), N, N-dialkylamine (C1-C6), NHSO2CH3 or COOCH3; or a 5- to 6-membered heteroaryl group optionally substituted with 1 or 2 substituents independently selected from the group consisting of amino, (C1-C4) alkyl, halo or hydroxy or a pharmaceutically acceptable salt thereof. |