abstract |
A derivative of the α-amino hydroxamic acid of the formula I, ** (See formula) ** wherein R1 is a hydrogen, C1-C7 alkyl, or substituted or unsubstituted carbocyclic C1-C7 alkyl; R2 is a hydrogen or C1-C7 alkyl; R3 is a substituted or unsubstituted C3-C7 cycloalkyl; phenyl which is unsubstituted or mono- or disubstituted by a halogen, C1-C4 alkoxy, C1-C7 alkyl, di-C1-C7-amino alkyl, triazolyl, imidazolyl, morpholinyl, pyrrolidinyl, piperidinyl, tetrazolyl, pyrrolinyl, furyl, thienyl , morpholinyl-C1-C7 alkyl, quinolinyl-C1-C7 alkyl, imidazolyl-C1-C7 alkyl and triazolyl-C1-C7 alkyl; pyridyl, quinolyl, isoquinolyl, benzothienyl, benzofuranyl, benzopyranyl, benzothiopyranyl, furanyl, pyrrolinyl, thiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl, pyrrazolyl, imidazolyl, thienyl, or any cited radical substituted by a C1-alkyl or halogen; piperidinyl, morpholinyl, pyrrolidinyl, pyrrolinyl, piperazinyl and tetrahydropyranyl unsubstituted or substituted by a C1-C7 alkyl; or C1-C7 alkyl; A is a C1-C3 alkylene unsubstituted or substituted by a C1-C7 alkyl; q is 1 or 2; R is an unsubstituted C3-C5 alkenyl, in which the double bond is located in the terminal position; or unsubstituted C3-C5 alkynyl, in which the triple bond is located in the terminal position; and pharmaceutically acceptable salts thereof; |