| abstract |
Use of influenza virosomes, formed from reconstituted envelopes of said virus, in the manufacture of a composition for a single intranasal administration to a human being and capable of inducing a systemic and / or local immune response against hemagglutinin influenza antigens and / or neuraminidase or derivatives thereof, wherein said composition comprises influenza virosomes formed from reconstituted envelopes of said virus, wherein: - viral envelopes are obtained entirely from viral influenza particles, - no lipid is added from sources external to the reconstituted virosomes, - the virosomes comprise hemagglutinin and / or influenza neuraminidase, or derivatives thereof, - the dose of hemagglutinin by viral strain and by a single intranasal or inhalation administration is less than or equal to 30 μg, characterized in that no separate adjuvant or / or immunity enhancer is added to the composition on. |