http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2337727-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 |
| filingDate | 2006-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ce528588d19a6aad057228defca753b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b92d8df1acafdc19fd74b0cc34cdef6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_380970ac14f046c35f020e4da9d3c2e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30d9ca20ab0d3ed8f5030c5403a061b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68c90e670ae6eb09e7c96def9c10513b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16deebcbb635d062421b7a1a09a94bdf |
| publicationDate | 2010-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2337727-T3 |
| titleOfInvention | USED PIPERIDINE DERIVATIVES AS H3 HISTAMINE ANTAGONISTS. |
| abstract | A compound represented by the structural formula ** (See formula) ** or a pharmaceutically acceptable salt thereof, where: a is 0, 1 or 2; b is 0, 1 or 2; n is 2; P is 2; M1 is N; M2 is CH or CF; M3 is N; Y is -C (= O) -, -C (= S) -, - (CH2) q-, -C (= NOR7) - or -SO1-2-; q is 1, 2, 3, 4 or 5, with the proviso that when M1 and M2 are both N, q is 2, 3, 4 or 5; X is -N (R4) -, -N (R4) -CH (R19) -, -CH (R19) -N (R4) -, -CH (R19) CH (R19) N (R4) -, - ( CH2), - C (O) -N (R4) -, -O- (CH2) 2-C (O) -N (R4) -, -CH2-O- (CH2) 3-C (O) -N (R4) -, - (CH2) tN (R4) -C (O) -, -C (O) -N (R4) -CH2-, - (CH2) tN (R18) C (O) N (R19) -, -N (R15) C (O) N (R19) - (CH2) t-, - (CH2) t-OC (O) N (R19) -, -N (R19) C (O) O-, -O-, -OCH2-, CH2O-, -OC (O) -, -C (O) O-, OCH (R19) -, -CH (R19) O- or -S-; r is 0, 1, 2 or 3; t is 0 or 1; Z is -CH2; R1 is H, R10-alkyl, R10-cycloalkyl, R10-aryl, R10-monoheteroaryl, R10-heterocycloalkyl, or a group of the formula: ** (See formula) ** where ring A is a monoheteroaryl ring, having said monoheteroaryl or monoheteroaryl ring of 1 to 4 heteroatoms selected from O, S and N, said heteroatoms interrupting an aromatic carbocyclic ring structure having 1 to 6 carbon atoms; R2 is R16-aryl, R16-heteroaryl, R16-cycloalkyl or R16-heterocycloalkyl; R3 is H. alkyl, R21-aryl, -R22-cycloalkyl, R22-heterocycloalkyl, R21-heteroaryl or-C (O) NH2; R4 is H, alkyl, haloalkyl, R18-aryl, R16-heteroaryl, R18-arylalkyl, -C (O) R12 or -SO2R13; each of R5 and R6 is independently selected from the group consisting of halo alkyl, -OH, alkoxy, haloalkyl and -CN; or two R5 substituents on the same carbon atom or two R6 substituents on the same carbon atom form = O; R7 is H, alkyl, haloalkyl, R10-aryl or R10-heteroaryl; each R9 is independently selected from the group consisting of H and alkyl; R10 is 1, 2, 3 or 4 substituents independently selected from the group consisting of H, halo, alkyl, R10 '' -cycloalkyl, -OH, alkoxy, R10 '' -aryl, R10 '' -arylalkyl, R10 '' -heteroaryl, R10 '' - heterocarkylalkyl, R10-aryloxy, haloalkyl, haloalkoxy, -NO2, -C (O) -alkyl, -C (O) -heterocycloalkyl, -CO2R11, -N (R11) 2, -CON (R11 ) 2, -NHC (O) R11, -NHC (O) -alkoxyalkyl-, -NHC (O) -CH2-NHC (O) CH3, -NHSO2R11, -CH (= NOR19), -SO2N (R11) 2, -SO2CF3 and -CN; each R10 '' is 1, 2, 3 or 4 substituents independently selected from the group consisting of H, halo, alkyl, cycloalkyl, -OH, alkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, haloalkyl, haloalkoxy, -NO2 , -C (O) -alkyl, -C (O) -heterocycloalkyl, -CO2R11, -N (R11) 2, -CON (R11) 2, -NHC (O) R11, -NHC (O) -alkoxyalkyl-, NHC (O) -CH2-NHC (O) CH3, -NHSO2R11, -CH (= NOR19), -SO2N (R11) 2, -SO2CF3 and -CN; each R11 is independently selected from the group consisting of H, alkyl, haloalkyl, R18-aryl, R18-heteroaryl, R18-arylalkyl, R18-cycloalkyl and R18-heterocycloalkyl; R12 is alkyl, R18-cycloalkyl, R18-aryl, R18-heteroaryl or R18-heterocycloalkyl; R13 is alkyl, R18-aryl or alkylsulfonylalkyl; R16 is 1, 2 or 3 substituents independently selected from the group consisting of H, halo, alkyl, R10-cycloalkyl, -OH, alkoxy, hydroxyalkyl, R10-aryl, R10-heteroaryl, R10-heterocycloalkyl, R10-aryloxy, haloalkyl , haloalkoxy, -NO2, -CO2R17, -N (R17) 2, -alkylene-N (R17) 2, -CON (R17) 2, -NHC (O) R17, -NHC (O) OR17, -NHSO2R17, - SO2N (R17) 2 and -CN; each R17 is independently selected from the group consisting of H, alkyl, haloalkyl, R18-aryl, R18-heteroaryl, R18-cycloalkyl and R18-heterocycloalkyl; R18 is 1, 2 or 3 substituents independently selected from the group consisting of H, alkyl, halo, alkoxy, haloalkyl, -NO2, -CN and -alkylene-N (R17) 2; each R17 is independently selected from the group consisting of H, alkyl, haloalkyl aryl, heteroaryl, cycloalkyl and heterocycloalkyl; R19 is independently selected from the group consisting of H and alkyl; R21 is 1, 2, 3 or 4 substituents independently selected from the group consisting of H, halo, alkyl, -OH, alkoxy, haloalkyl, haloalkoxy, -NO2, -CN, -C (O) N (R19) 2 and - N (R19) 2; and R22 is 1, 2 or 3 substituents independently selected from the group consisting of halo, alkyl, -OH, alkoxy, haloalkyl, -NO2 and -CN-. |
| priorityDate | 2005-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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