http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2337559-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82c5b228ac144749836ee7461e517127 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-255 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-554 |
| filingDate | 2002-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5aaced205a599f8bc0c41c5b24cd7b21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0e161d78a64b14323b9d476888b6240 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aac1ef77b1ca0b5c589211f9f996554a |
| publicationDate | 2010-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2337559-T3 |
| titleOfInvention | DERIVATIVES OF BENZOTIAZEPINE FOR THE TREATMENT OF HYPERLIPIDEMIA. |
| abstract | Compound of formula (I): ** (See formula) ** in which one of R1 and R2 is selected from hydrogen, C1-6 alkyl or C2-6 alkenyl, and the other is selected from C1- alkyl 6 or C2-6 alkenyl; Ry is selected from hydrogen, hydroxy, C1-6 alkyl C1-4 alkoxy and C1-6 alkanoyloxy; Rz is selected from halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, sulfamoyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 alkanoyl, C1 alkanoyloxy -6, N- (C1-6 alkyl) amino, N, N- (C1-6 alkyl) 2amino, C1-6 alkanoylamino, N- (C1-6 alkyl) carbamoyl, N, N- (C1-6 alkyl) 2carbamoyl, (C1-6 alkyl) S (O) a, wherein a is 0 to 2, C1-6 alkoxycarbonyl, N- (C1-6 alkyl) sulfamoyl and N, N - ([C1-6 alkyl) 2sulfamoyl ; v is 0-5; one of R4 and R5 is a group of formula (IA): ** (See formula) ** R3 and R6, and the other between R4 and R5, are independently selected from hydrogen, halo, nitro, cyano, hydroxy , amino, carboxy, carbamoyl, mercapto, sulfamoyl, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, C1-4 alkanoyl, C1-4 alkanoyloxy, N- (C1-4 alkyl) amino , N, N- (C1-4 alkyl) 2amino, C1-4 alkanoylamino, N- (C1-4 alkyl) carbamoyl, N, N- (C1-4 alkyl) 2carbamoyl, (C1-4 alkyl) S (O) a, wherein a is 0 to 2, C1-4 alkoxycarbonyl, N- (C1-4 alkyl) sulfamoyl and N, N- (C1-4 alkyl) 2sulfamoyl; wherein R3 and R6 and the other between R4 and R5 may optionally be substituted on the carbon by one or more R16; X is -O-, -N (Ra) -, -S (O) b- or -CH (Ra) -; wherein Ra is hydrogen or C1-6 alkyl and b is 0-2; ring A is aryl or heteroaryl; wherein ring A is optionally substituted by one or more substituents selected from R17; R7 is hydrogen, C1-4 alkyl, carbocyclyl or heterocyclyl; in Is that R7 is optionally substituted by one or more substituents selected from R18; R8 is hydrogen or C1-4 alkyl; R9 is hydrogen or C1-4 alkyl; R 10 is hydrogen, C 1-4 alkyl, carbocyclyl or heterocyclyl; wherein R10 is optionally substituted by one or more substituents selected from R19; R11 is carboxy, sulfo, sulfine, phosphono, -P (O) (ORc) (ORd), -P (O) (OH) (ORc), -P (O) (OH) (Rd) or -P (O ) (ORc) (Rd), in which Rc and Rd are independently selected from C1-6 alkyl; or R11 is a group of formula (IB): ** (See formula) ** in which Y is -N (Rx) -, -N (Rx) C (O) -, -O-, and -S ( O) a-; wherein a is 0-2 and Rx is hydrogen or C1-4 alkyl; R12 is hydrogen or C1-4 alkyl; R13 and R14 are independently selected from hydrogen, C1-6 alkyl, carbocyclyl or heterocyclyl; wherein R13 and R14 may optionally be independently substituted by one or more substituents selected from R20; R15 is carboxy, sulfo, sulfine, phosphono, -P (O) (ORe) (ORf), -P (O) (OH) (ORe), -P (O) (OH) (Re) or -P (O ) (ORe) (Rf), in which Re and Rf are independently selected from C1-6 alkyl; or R15 is a group of formula (IC): ** (See formula) ** in which R24 is selected from hydrogen or C1-4 alkyl; R25 is selected from hydrogen, C1-4 alkyl, carbocyclyl, heterocyclyl or R27; wherein said C1-4 alkyl, carbocyclyl or heterocyclyl can be optionally independently substituted by one or more substituents selected from R28; R26 is selected from carboxy, sulfo, sulfine, phosphono, tetrazolyl, -P (O) (ORg) (ORh), -P (O) (OH) (ORg), -P (O) (OH) (Rg) or -P (O) (ORg) (Rh), wherein R9 and Rh are independently selected from C1-6 alkyl; p is 1-3; in which the values of R13 may be identical or different; q is 0-1; r is 0-3; in which the values of R14 may be identical or different; m is 0-2; in which the values of R10 may be identical or different; n is 1-3; in which the values of R7 may be identical or different; z is 0-3; in which the values of R25 may be identical or different; R16, R17 and R18 are independently selected from halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, sulfamoyl, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, C1 alkanoyl -4, C1-4 alkanoyloxy, N- (C1-4 alkyl) amino, N, N- (C1-4 alkyl) 2amino, C1-4 alkanoylamino, N- (C1-4 alkyl) carbamoyl, N, N- ( C1-4 alkyl) 2carbamoyl, (C1-4 alkyl) S (O) a, wherein a is 0 to 2, C1-4 alkoxycarbonyl, N- (C1-4 alkyl) sulfamoyl and N, N- (C1 alkyl -4) 2sulfamoyl; wherein R16, R17 and R18 may optionally be independently substituted on the carbon by one or more R21; R19, R20, R27 and R28 are independently selected from halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, sulfamoyl, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, C1-4 alkanoyl, C1-4 alkanoyloxy, N- (C1-4 alkyl) amino, N, N- (C1-4 alkyl) 2amino, C1-4 alkanoylamino, N- (C1-4 alkyl) carbamoyl, N, N - (C1-4 alkyl) 2carbamoyl, (C1-4 alkyl) S (O) a, in which a is 0 to 2, C1-4 alkoxycarbonyl, N- (C1-4 alkyl) sulfamoyl, N, N- ( C1-4 alkyl) 2sulfamoyl, carbocyclyl, heterocyclyl, sulfo, sulfino, amidino, (C1-4 alkyl) 3sylyl, phosphono, -P (O) (ORa) (ORb), -P (O) (OH) (ORa) , -P (O) (OH) (Ra) or -P (O) (ORa) (Rb), in which Ra and Rb are independently selected from C1-6 alkyl; wherein R19 and R20 may optionally be independently substituted on the carbon by one or more R22; R21 and R22 are independently selected from halo, hydroxy, cyano, carbamoyl, ureido, amino, nitro, carboxy, carbamoyl, mercapto; sulfamoyl, trifluoromethyl, trifluoromethoxy, methyl, ethyl, methoxy, ethoxy, vinyl, allyl, ethynyl, methoxycarbonyl, formyl, acetyl, formamide, acetylamino, acetoxy, methylamino, dimethylamino, N-methylcarbamoyl, N, N-dimethylcarbamoyl, methyl, methylamino, methyl mesyl, N-methylsulfamoyl and N, N-dimethylsulfamoyl; wherein "heteroaryl" is a fully unsaturated mono or bicyclic ring containing 3-12 atoms of which at least one atom is selected from nitrogen, sulfur or oxygen, which, unless otherwise specified, may be bonded carbon or nitrogen; "aryl" is a fully unsaturated mono or bicyclic carbon ring containing 3-12 atoms; a "heterocyclyl" is a saturated mono or bicyclic ring, partially saturated or unsaturated, containing 3-12 atoms, of which at least one atom is selected from nitrogen, sulfur or oxygen, which, unless specified on the contrary, it can be carbon or nitrogen bound, in which a group -CH2- can be optionally substituted by a -C (O) -, or a ring sulfur atom can be optionally oxidized to form the oxides of S; and a "carbocyclyl" is a saturated, partially saturated or unsaturated mono or bicyclic carbon ring containing 3-12 atoms; in which a group -CH2- may be optionally substituted by -C (O) -; or a salt, solvate, solvate of said pharmaceutically acceptable salt thereof. |
| priorityDate | 2001-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 375.