abstract |
Extruded multiparticulates, in molten state, controlled release, containing (a) oxycodone, (b) water insoluble ammonium methacrylate copolymer, (c) plasticizer, (d) lubricant and (e) water permeability modifier, wherein said water permeability modifier is a water permeable ammonium methacrylate copolymer or hydroxypropyl methyl cellulose. |