| abstract |
Recombinant adenovirus vector comprising structural and non-structural elements of an adenovirus of a first serotype, wherein said vector further comprises a sequence encoding a functional E4-orf6 protein, wherein said sequence is selected from the group consisting of : a) a sequence encoding for E4-orf6 of an adenovirus of a second serotype different from said first serotype; and b) a sequence coding for E4-orf6 comprising a fusion between a part of a sequence coding for E4-orf6 of a second serotype different from said first serotype and a part of a sequence coding for E4-orf6 of a third serotype, wherein said third serotype may be identical to or different from said first serotype. |