http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2335519-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a70b05f3bdf7f6e9aaf7a41ac3aacdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2005-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f11e364b050d23f6057b7ed924f35035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b48f5e2dca8761f0330a7cabe4464755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efb3656878aa9af7ce4a34a049c8db72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5ddac15e2a5328056ebbad9b2417a1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c1ce39966934342cc20ecd0a6c6f1fc |
| publicationDate | 2010-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2335519-T3 |
| titleOfInvention | PIRROL DERIVATIVES THAT HAVE ANALOGONIST ACTIVITY OF THE CRTH2 RECEIVER. |
| abstract | A compound of formula (I) ** (See formula) ** in free form or pharmaceutically acceptable salt, wherein Q is ** (See formula) ** R1 and R2 are, independently, H, C1-C6 alkyl, or together with the carbon atom to which they bind form a divalent C3-C8 cycloaliphatic group; R3 and R4 are independently selected from H and C1-C8 alkyl; R3 is cyano; R6 is selected from H, halogen, C1-C8 alkyl, C1-C8 haloalkyl, a C3-C15 carbocyclic group, nitro, cyano, SO2R6a, C1-C8 alkylcarbonyl, C1-C8 alkoxycarbonyl, C1-C8 alkoxy, C1-C8 haloalkoxy , -SR6b, carboxy, carboxy-C1-C8 alkyl) amino, amino (C1-C8 alkyl), C1-C8 alkylamino (C1-C8 alkyl), di (C1-C8 alkyl) amino (C1-C8 alkyl), alkylamino C1-C8, di (C1-C8 alkyl) amino, SO2NR6cR6d, -C (O) NR6eR6f, hydroxyalkyl C1-C8, NR6gSO2R6h, NR6i (CO) R6j, SOR6k, a C8-C15 aromatic carbocyclic group and a heterocyclic group of 4 - to 10-members having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; R6a, R6k and R6b are independently selected from C1-C8 alkyl, C1-C8 hydroxyalkyl, C1-C8 alkylamino (C1-C8 alkyl), di (C1-C8 alkyl) amino (C1-C8 alkyl), C1-C8 cyanoalkyl, a C3-C15 carbocyclic group, C1-C8 haloalkyl and a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; R6c, R6d, R6e and R6f are independently H, C1-C8 alkyl, C1-C8 hydroxyalkyl, C1-C8 alkylamino (C1-C8 alkyl), di (C1-C8 alkyl) amino (C1-C8 alkyl), C1- cyanoalkyl C8, a C3-C15 carbocyclic group, C1-C6 haloalkyl, a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, or together with the nitrogen atom at which bind form a C4-C10 heterocyclic group; R6g and R6i are independently selected from H, C1-C8 alkyl, C1-C8 hydroxyalkyl, C1-C8 alkylamino (C1-C8 alkyl), di (C1-C8 alkyl) amino (C1-C8 alkyl), C1-C8 cyanoalkyl, a C3-C15 carbocyclic group, C1-C8 haloalkyl and a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; R6h and R6j are independently selected from C1-C8 alkyl, a C3-C15 carbocyclic group, a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, C1- hydroxyalkyl C8, amino (C1-C8 alkyl), C1-C8 alkylamino (C1-C8 alkyl), di (C1-C8 alkyl) amino (C1-C8 alkyl), and C1-C8 cyanoalkyl; W is selected from the C3-C15 carbocyclic group and 4- to 10-membered heterocycle having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; m is an integer selected from 1-3; and n is an integer selected from 1-4; with the proviso that the compounds [3-cyano-4- (2,3-dichloro-phenyl) -pyrrol-1-yl] -acetic acid are excluded; N- (2-Carboxyethyl) -3-cyano-4- (2,3-dichloro-phenyl) pyrrole; N- (3-carboxypropyl) -3-cyano-4- (2,3-dichloro-phenyl) pyrrole and N- (1-carboxyethyl) -3-cyano-4- (2,3-dichloro-phenyl) -pyrrole . |
| priorityDate | 2004-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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