| abstract |
A compound of formula I, or a salt thereof, ** (See formula) ** in which: W, X and Y are chosen independently of -CH = and -N =, and two or more of W, Y and X are = N-; V is -NR5, or -O-; Z is -N (R1) (R2), -S-aryl, or substituted S-aryl; R1 is hydrogen or alkyl; R2 is alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, heteroaryl or substituted heteroaryl; R5 is hydrogen; R7 is hydrogen, alkyl, substituted alkyl, alkoxy or halogen; R8 is hydrogen; R9 is -C (O) R10; R10 is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl or substituted heteroaryl, or N (R31) (R32); R31 is hydrogen, alkyl or substituted alkyl; R32 is hydrogen, alkyl, substituted alkyl, alkoxy, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, heteroaryl or substituted heteroaryl; R11 is -N (R12) (R13); R12 is hydrogen, alkyl or substituted alkyl; R13 is - (CH2) mR14; m is 1, 2 or 3; R14 is hydrogen, alkyl, substituted alkyl, -C (O) N (R31) (R32), N (R33) C (O) R34, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, heteroaryl or heteroaryl substituted or ** (See formula) ** R15 is hydrogen, alkyl or substituted alkyl; R16 is hydrogen or alkyl; or -N (R12) (R13) taken together may form a substituted heterocyclyl or heterocyclyl; R33 is hydrogen, alkyl or substituted alkyl; and R34 is alkyl, substituted alkyl, aryl or substituted aryl, with the proviso that the compound of formula ** (See formula) ** is excluded, so that alkyl means linear or branched hydrocarbon structures and combinations thereof of 1 to 20 carbons; lower alkyl means alkyl groups of 1 to about 10; aryl means an aromatic hydrocarbon radical of 6 to about 16 carbon atoms, preferably 6 to about 12 carbon atoms and, more preferably, 6 to about 10 carbon atoms; Cycloalkyl refers to saturated hydrocarbon ring structures of 3 to 12 carbon atoms and, preferably, 3 to 6 carbon atoms; lower cycloalkyl refers to cycloalkyl of 3 to 6 carbon atoms; "heterocyclyl" refers to saturated or partially saturated structures of 3 to 8 atoms, and bicyclic structures of 9 or 10 atoms containing one or more carbon atoms and 1 to 4 heteroatoms chosen from O, N and S; heteroaryl refers to unsaturated structures of 5 to 6 atoms and bicyclic structures of 9 or 10 atoms containing one or more carbons and 1 to 4 heteroatoms chosen from O, N and S; alkoxy means a linear, branched or cyclic hydrocarbon configuration and combinations thereof, including 1 to 20 carbon atoms; and an oxygen atom at the point of attachment; Lower alkoxy refers to alkoxy groups having 1 to 4 carbon atoms; "alkylthio" refers to said groups having a sulfur atom at the point of attachment; alkenyl refers to an unsaturated acyclic hydrocarbon radical so that it contains at least one double bond, lower alkenyl refers to said radicals containing from about 2 to about 10 carbon atoms; Alkynyl refers to an unsaturated acyclic hydrocarbon radical containing at least one triple bond; substituted alkyl means an alkyl in which one or more hydrogens, preferably one, two or three hydrogens, bonded to an aliphatic carbon are substituted with a substituent such as -N (R31) (R32), alkoxy, alkylthio, halogen, cyano, carboxyl, hydroxyl, -SO2-alkyl, CO2-alkyl, -C (O) -alkyl, nitro, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl, substituted heteroaryl, -C (O) -N (R31) (R32) or -NH-C (O) -alkyl; substituted cycloalkyl means a cycloalkyl in which one or more hydrogens, preferably one, two or three hydrogens, attached to a ring carbon are substituted with a substituent such as alkyl, substituted alkyl, N (R31) (R32), alkoxy, alkylthio , aryl, substituted aryl, halogen, cyano, carboxyl, hydroxyl, nitro, SO2-alkyl, -CO2-alkyl, C (O) -alkyl, -C (O) -N (R31) (R32), or -NH- C (O) -alkyl, this definition also includes cycloalkyl rings that have a fused ring, ** (See formula) ** And the like; substituted aryl means an aryl in which one or more hydrogens, preferably one, two or three hydrogens, bonded to an aromatic carbon are substituted with a substituent such as alkyl, substituted alkyl, N (R31) (R32), alkoxy, alkylthio, aryl, substituted aryl, halogen, cyano, nitro, carboxyl, hydroxyl, SO2-alkyl, -CO2-alkyl, C (O) -alkyl, -C (O) -N (R31) (R32), or -NH-C (O) -alkyl; substituted heteroaryl or substituted heterocyclyl means a heteroaryl or substituted heterocyclyl at one or more available carbon or nitrogen atoms, preferably at one or two carbon and / or nitrogen atoms, with a substituent such as alkyl, substituted alkyl, -N (R31) (R32), alkoxy, alkylthio, aryl, substituted aryl, halogen, cyano, nitro, oxo, carboxyl, hydroxyl, -SO2-alkyl, -CO2-alkyl, -C (O) -alkyl, -C (O) -N (R31) (R32), or -NH-C (O) -alkyl. |