| abstract |
1. Compounds of the general formula ** (See formula) ** in which R1 is halogen, -OR1 '', -SR1 '' '' cycloalkyl, cyclic amide, heterocycloalkyl, aryl or heteroaryl of 5 or 6 links containing one, two or three heteroatoms chosen from the group consisting of oxygen, sulfur and nitrogen; R1 '' / R1 '' '' are hydrogen, C1-6 alkyl, halogen substituted C1-6 alkyl, - (CH2) x-cycloalkyl or - (CH2) x-aryl; R2 is -S (O) 2-C1-6 alkyl, -S (O) 2NH-C1-6 alkyl, NO2 or CN; ** (See formula) ** is an aromatic or partially aromatic bicyclic amine, which may contain one or two additional N atoms, chosen from the group consisting of ** (See formula) ** and in which one of the atoms Additional N-ring of the aromatic or partially aromatic bicyclic amine may be available as an oxide ** (See formula) ** from R3 to R10 are hydrogen, hydroxy, halogen, = O, C1-6 alkyl, cycloalkyl, heterocycloalkyl, C1-6 alkoxy, CN, NO2, NH2, aryl, 5- or 6-link heteroaryl containing one, two or three heteroatoms, selected from the group consisting of oxygen, sulfur and nitrogen, -NH-C1-6 alkyl, -N (C1-6 alkyl) 2, cyclic amide, -C (O) -cyclic amide, S-C1-6 alkyl, -S (O) 2-C1-6 alkyl, C1-6 alkyl substituted by halogen, C1- alkoxy 6 substituted by halogen, C1-6 alkyl substituted by hydroxy, -O- (CH2) and -C 1-6 alkoxy, -O (CH2) and C (O) N (C1-6 alkyl) 2, -C (O) - C1-6 alkyl, -O- (CH2) x-aryl, -O- (CH2) x-cycloalkyl, -O- (CH2) x-heter ocycloalkyl, -C (O) O-C1-6 alkyl, -C (O) -NH-C1-6 alkyl, -C (O) -N (C1-6 alkyl) 2, 2-oxy-5-aza- bicyclo [2.2.1] hept-5-yl or 3-oxa-8-aza-bicyclo [3.2.1] oct-8-yl; R '' and R '' '' '' of group e) can form together with - (CH2) 4- a six-link ring; or R, R '', R '' '' and R '' '' '' independently of one another are hydrogen or C1-6 alkyl; and wherein all aryl, cycloalkyl, cyclic amide, heterocycloalkyl or heteroaryl groups of 5 or 6 links defined for R1, R1 '', R1 '' '' and R3 to R10 may be unsubstituted or substituted by one or more substituents chosen from the group consisting of hydroxy, = O, halogen, C1-6 alkyl, phenyl, C1-6 alkyl substituted by halogen and C1-6 alkoxy; n, m, o, p, q, r, s and t are the number 1 or 2; x is 0, 1 or 2; y is 1 or 2; and pharmaceutically acceptable acid addition salts thereof, with the exception of (2-hydroxy-5-nitro-phenyl) - (6-nitro-indazol-1-yl) methanone. |