http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2333956-T3
Outgoing Links
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-10 |
| filingDate | 2003-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb115eb217a169846fe32e6454c3f854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e9f7e47b43496d9228cf0b31c24f166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9535c0870551a5120bf8aa4c9d422f05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ec80223d4e582443c0775dcc4d8a1ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8bba50f9909cea2d5780568aaa7c75a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7509f264adda67c49fe8505a39420f4 |
| publicationDate | 2010-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2333956-T3 |
| titleOfInvention | SPIROCICLIC CYCLHEXAN DERIVATIVES. |
| abstract | Spirocyclic cyclohexane derivatives of general formula I, ** (See formula) ** where R1 and R2 represent, independently of each other, H, branched or unbranched, saturated or unsaturated (C1-5) alkyl, unsubstituted, or CHO; or the groups R1 and R2 together represent CH2CH2OCH2CH2, CH2CH2NR11CH2CH2 or (CH2) 3-6; R11 being equal to H or (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted; R3 represents (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl, in each case substituted simply or multiplely or unsubstituted; or aryl or (hetero) C3-8 cycloalkyl, in each case substituted in a simple or multiple or unsubstituted form, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; W represents NR4, O or S; R4 being equal to H, saturated or unsaturated (C1-5) alkyl, branched or unbranched, substituted simply or multiple or unsubstituted; or substituted or unsubstituted aryl; R12 being equal to H, (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl or heteroaryl, in each case substituted simply or multiplely or unsubstituted; or aryl, (hetero) (C3-8) cycloalkyl or heteroaryl, in each case substituted in a simple or multiple or unsubstituted form, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or not branched; OR13; or NR14R15; R5 represents = O; H; COOR13, CONR13, OR13; (C1-5) alkyl saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; or single or multiple or unsubstituted substituted aryl, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; R6 represents H; F, Cl, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, CN, COOR13, NR14R15; (C1-5) alkyl saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; aryl substituted single or multiple or unsubstituted; or single or multiple or unsubstituted substituted aryl, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; or R5 and R6 together represent (CH2) n, with n = 2, 3, 4, 5 or 6, some individual hydrogen atoms can also be substituted by F, Cl, Br, I, NO2, CF3, OR13, CN or (C1-5) alkyl; R7, R8, R9 and R10 represent, independently of each other, H, F, Cl, Br, I, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, SO2NH2, CN, COOR13, NR14R15; (C1-5) alkyl, (hetero) C3-8 cycloalkyl, substituted in single or multiple or unsubstituted; aryl or heteroaryl substituted single or multiple or unsubstituted; or aryl, (hetero) C3-8 cycloalkyl or substituted or single or unsubstituted heteroaryl, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; R13 being equal to H, (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted; or (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, unsubstituted; R14 and R15 mean, independently of each other, H, (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted; or R14 and R15 together form CH2CH2OCH2CH2, CH2CH2NR16CH2CH2 or (CH2) 3-6, R16 being equal to H or (C1-5) alkyl saturated or unsaturated, branched or unbranched, unsubstituted; X represents O, S, SO, SO2 or NR17; R17 H, (C1-5) alkyl saturated or unsaturated, branched or unbranched; COR12 or SO2R12; and in the case of groups R3, R4, R5, R6, R7, R8, R9 and R10 by the concept "substituted" in relation to "alkyl" means the substitution of one or more hydrogen groups by F, Cl, Br , I, -CN, NH2, NH-alkyl, NH- (hetero) cycloalkyl, NH-alkyl-OH, N (alkyl) 2, N ((hetero) cycloalkyl) 2, N (alkyl-OH) 2, NO2, SH, S-alkyl, S- (hetero) cycloalkyl, S-alkyl-OH; S-alkyl-SH, OH, O-alkyl, O- (hetero) cycloalkyl, O-alkyl-OH, CHO, C (= O) (C1-6) alkyl, C (= S) (C1-6) alkyl , C (= O) - (hetero) cycloalkyl, C (= S) - (hetero) cycloalkyl, CO2H, CO2-alkyl, C (= O) NH2, C (= O) NH-alkyl, C (= O) NH- (hetero) cycloalkyl, C (= O) N (alkyl) 2, C (= O) N ((hetero) cycloalkyl) 2, SO-alkyl, SO2-alkyl, SO2NH2, SO3H or (hetero) cycloalkyl; and in the case of the R5 group it is also possible in addition to the substitution of one or more hydrogen groups with O-aryl, the aryl being substituted simply or unsubstituted; and by the concept "substituted simply or multiplely" in relation to "aryl" and "(hetero) cycloalkyl" is meant single or multiple substitution, for example double, triple, quadruple or quintuple, of one or more hydrogen atoms of the ring system by F, Cl, Br, I, CN, NH2, NH-alkyl, NH- (hetero) cycloalkyl, NH-alkyl-OH, N (alkyl) 2, N ((hetero) cycloalkyl) 2, N (alkyl-OH) 2, NO2, SH, S-alkyl, S- (hetero) cycloalkyl, S-alkyl-OH, S-alkyl-SH, OH, O-alkyl, O- (hetero) cycloalkyl, O-alkyl -OH, CHO, C (= O) (C1-6) alkyl, C (= S) (C1-6) alkyl, C (= O) - (hetero) cycloalkyl, C (= S) - (hetero) cycloalkyl , CO2H, CO2-alkyl, C (= O) NH2, C (= O) NH-alkyl, C (= O) NH- (hetero) cycloalkyl, C (= O) N (alkyl) 2, C (= O ) N ((hetero) -cycloalkyl) 2, S (O) -alkyl, SO2-alkyl, SO2NH2, SO3H, CF3, = O, = S; alkyl or (hetero) cycloalkyl; and by the term "single or multiple substituted" in relation to "heteroaryl" is meant the simple or multiple substitution, for example double, triple, quadruple or quintuple, of one or more hydrogen atoms of the ring system by F, Cl, Br, I, CN, NH2, NH-alkyl, NH-aryl, NH-heteroaryl, NH-alkylaryl, NH-alkylheteroaryl, NH- (hetero) cycloalkyl, NH-alkyl-OH, N (alkyl) 2, N (alkylaryl) 2, N (alkylheteroaryl) 2, N ((hetero) cycloalkyl) 2, N (alkyl-OH) 2, NO2, SH, S-alkyl, S- (hetero) cycloalkyl, S-aryl, S-heteroaryl , S-alkylaryl, S-alkylheteroaryl, S-alkyl-OH, S-alkyl-SH, OH, O-alkyl, O- (hetero) cycloalkyl, O-aryl, O-heteroaryl, O-alkylaryl, O-alkylheteroaryl, O-alkyl-OH, CHO, C (= O) (C1-6) alkyl, C (= S) (C1-6) alkyl, C (= O) - (hetero) cycloalkyl, C (= S) - ( hetero) cycloalkyl, CO2H, CO2-alkyl, C (= O) NH2, C (= O) NH-alkyl, C (= O) NH- (hetero) cycloalkyl, C (= O) N (alkyl) 2, C (= O) N ((hetero) cycloalkyl) 2, S (O) -alkyl, SO2-alkyl, SO2NH2, SO3H, CF3, = Or, = S; alkyl, (hetero) cycloalkyl, aryl and / or heteroaryl; the term "aryl" means a carbocyclic ring system with at least one aromatic ring but without heteroatoms in any of the rings, the aryl groups being able to be condensed with other saturated, (partially) unsaturated or aromatic ring systems; the term "heteroaryl" represents a cyclic aromatic group of 5, 6 or 7 members that contains at least 1 and if necessary also 2, 3, 4 or 5 heteroatoms, the heteroatoms being the same or different, nitrogen, oxygen or sulfur and the heterocycle may also be part of a bicyclic or polycyclic system; the expression "(hetero) cycloalkyl" represents a cyclic hydrocarbon of 3, 4, 5, 6, 7 or 8 carbon atoms, the hydrocarbons may be saturated or unsaturated, but not aromatic, and one or two carbon atoms may be substituted if necessary by a heteroatom S, N or O; in the form of racemate, enantiomers, diastereoisomers, mixture of enantiomers or diastereoisomers or of an individual enantiomer or diastereoisomer; in the form of bases and / or salts of physiologically compatible acids or cations. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10912763-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9289416-B2 |
| priorityDate | 2002-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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