abstract |
A fusion polypeptide comprising (i) an MTB39 antigen (SEQ ID No. 12 or 14), a variant of said MTB39 antigen that has at least 90% identity with the same or an immunogenic fragment of said MTB39 antigen, and ( ii) an MTB32A antigen (SEQ ID NO: 2 or 4), a variant of said MTB32A antigen having at least 90% identity with it or an immunogenic fragment of said MTB32A antigen, characterized in that said MTB32A antigen, variant or fragment it has an amino acid substitution corresponding to position 183 of SEQ ID No. 4 or amino acid position 208 of SEQ ID No. 2, in which the serine residue usually found in this position has been replaced by another amino acid. |