| abstract |
A method of generating a cell line that is capable of complementing recombinant adenoviruses with suppressed E1, which comprises providing a human cell with a nucleic acid molecule that comprises adenoviral E1 sequences encoding functional E1A and E1B gene products and lacking pIX sequences, to integrate the nucleic acid molecule into the genome of said human cell and to express E1A, E1B 55 kD and E1B 21 kD in said cell. |