http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2332416-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 |
| filingDate | 2005-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36c31b99f5d255ce69d85ffb3edf464a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5831eef0f5db02e824db531827f5fc0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b150a081799c8628580448941698fbff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fef2b710f4c8c9d381b119b6dc17286 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dacfbe81667d5b2c84aafe6d3653065c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95537c555291c002b6adf9d8b440a0ef |
| publicationDate | 2010-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2332416-T3 |
| titleOfInvention | CANNABINOID RECEIVERS LINKS. |
| abstract | A compound of Formula I: ** (See formula) ** or a pharmaceutically acceptable salt or solvate of said compound, wherein: A is selected from the group consisting of phenyl, naphthyl, pyridyl, thiophenyl, thiazolyl, indolyl, azaindolyl, quinolyl , isoquinolinyl, pyrazinyl, pyridazinyl, furanyl, pyrrolyl, pyrimidinyl, cinolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, benzofuranyl, and benzothiophenyl; B is selected from Formulas B1-B6: ** (See formula) ** Each Y is independently selected from the group consisting of - (C (R7) 2) p-, -O- (C (R7) 2) q -, - (C (R7) 2) qO-, -S- (C (R7) 2) r-, - (C (R7) 2) rS-, -S (O) - (C (R7) 2) r-, - (C (R7) 2) rS (O) -, -S (O2) - (C (R7) 2) r-, - (C (R7) 2) rS (O2) -, -N ( R7) - (C (R7) 2) r-, and - (C (R7) 2) rN (R7) -; each Z is independently selected from the group consisting of - (C (R7) 2) p-, -O- (C (R7) 2) q-, - (C (R7) 2) qO-, -S- (C (R7) 2) r-, - (C (R7) 2) rS-, -S (O) - (C (R7) 2) r-, - (C (R7) 2) rS (O) -, - S (O2) - (C (R7) 2) r-, - (C (R7) 2) rS (O2) -, -N (R7) - (C (R7) 2) r-, and - (C ( R7) 2) rN (R7) -; p is an integer from 1 to 3; q is 1 or 2; r is an integer from 0 to 2; s is 0 or 1, so when s is 0, Z is a covalent bond and B has a bicyclic structure; L1 is selected from the group consisting of a covalent bond, - (C (R7) 2) p-, -C (O) -, -C (O) O-, -OC (O) -, -CH (OR7) -, -S (O2) -, -S (O) -, -S-, -O-, -N (R7) -, -C (O) N (R7) -, -N (R7) C (O ) -, -OC (O) N (R7) -, -N (R7) C (O) O-, -N (R7) C (O) N (R7) -, - CF2-, and -C (= N-OR7) -; L2 is -S (O) 2-; L3 is selected from the group consisting of a covalent bond, -C (R7) 2-, -C (O) -, -C (O) O-, -OC (O) -, -CH (OR7) -, - S (O2) -, -S (O) -, -S-, -O-, -N (R7) -, -C (O) N (R7) -, N (R7) C (O) -, - CF2-, and -C (= N-OR7) -; R1 is selected from the group consisting of H, alkyl, -CF3, -Si (alkyl) t (aryl) 3-t, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein each of said alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl may be unsubstituted or independently substituted with one or more substituents that may be the same or different and are independently selected from the group consisting of halogen, -OH, alkoxy, haloalkoxy, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, - N (R7) 2, -C (O) R7, -C (O) OR7, -OC (O) R7, -C (O) N (R7) 2, -N (R7) C (O) R7, - N (R7) C (O) OR7, -N (R7) C (O) N (R7) 2, -NO2, -CN, -S (O2) R7, -S (O2) N (R7) 2, and -N (R7) C (= N-CN) NHR7; t is an integer from 0 to 3; R2 is selected from the group consisting of H, -OH, halogen, -N (R7) 2, alkoxy, haloalkoxy, alkyl, haloalkyl, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, aryl, aryloxy, heteroaryl, and heteroaryloxy, where each of said alkoxy, haloalkoxy, alkyl, haloalkyl, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, aryl, aryloxy, heteroaryl, and heteroaryloxy can be independently unsubstituted or substituted with one or more substituents that may be the same or different and are independently selected from the group that consists of halogen, -OH, alkoxy, haloalkoxy, alkyl, haloalkyl, cycloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -N (R7) 2, -C (O) R7, -C (O) OR7, -OC (O ) R7, -C (O) N (R7) 2, -N (R7) C (O) R7, -N (R7) C (O) OR7, -N (R7) C (O) N (R7) 2 , -NO2, -CN, -S (O2) R7, -S (O2) N (R7) 2, and -N (R7) C (= N-CN) NHR7; n is an integer from 0 to 4; R3 and R4 are the same or different, and are independently H or alkyl, wherein said alkyl may be unsubstituted or independently substituted with one or more substituents that may be the same or different and are independently selected from the group consisting of halogen, -OH, alkoxy , haloalkoxy, alkyl, haloalkyl, alkoxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, aryl, aryloxy, heteroaryl, heteroaryloxy, -N (R7) 2, -C (O) R7, -C (O) OR7, -OC (O ) R7, -C (O) N (R7) 2, -N (R7) C (O) R7, -N (R7) C (O) OR7, -NR7C (O) N (R7) 2, -NO2, -CN, -S (O2) R7, -S (O2) N (R7) 2, and -N (R7) C (= N-CN) NHR7; or if B is one of Formulas B4-B6, R3 and R4, taken together with the carbon atom to which they are shown anchored in Formulas B4-B6, they form a carbonyl group; or R3 and R4, taken together with the carbon atom to which they are shown anchored in Formulas B4-B6, form a non-aromatic ring system, wherein said cycloalkyl or heterocycloalkyl ring may be unsubstituted or substituted independently with one or more substituents that they may be the same or different and are independently selected from the group consisting of halogen, -OH, alkoxy, haloalkoxy, alkyl, haloalkyl, alkoxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, aryl, aryloxy, heteroaryl, heteroaryloxy, -N (R7) 2, -C (O) R7, -C (O) OR7, -OC (O) R7, -C (O) N (R7) 2, -N (R7) C (O) R7, -N (R7) C (O) OR7, -NR7C (O) N (R7) 2, -NO2, -CN, -S (O2) R7, -S (O2) N (R7) 2, and -N (R7) C (= N-CN) NHR7; R5 is H and R6 selected from the group consisting of H, alkyl, haloalkyl, -CF3, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, where each of said alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl may be unsubstituted or independently substituted with one or more substituents that may be the same or different and are independently selected from the group consisting of halogen, -OH, alkoxy, haloalkoxy, alkyl, haloalkyl, alkoxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, aryl, aryloxy, heteroaryl, heteroaryloxy, - N (R7) 2, -C (O) R7, -C (O) OR7, -OC (O) R7, -C (O) N (R7) 2, -N (R7) C (O) R7, - N (R7) C (O) OR7, -N (R7) C (O) N (R7) 2, -NO2, -CN, -S (O2) R7, -S (O2) N (R7) 2, and -N (R7) C (= N-CN) NHR7; each R7 is independently selected from the group consisting of H, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, where each of said alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl may be unsubstituted or independently substituted with one or more substituents which they may be the same or different and are independently selected from the group consisting of halogen, -OH, alkoxy, haloalkoxy, alkyl, haloalkyl, alkoxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, aryl, aryloxy, heteroaryl, and heteroaryloxy; X is independently selected from the group consisting of H, halogen, alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, aryl, aryloxy, heteroaryl, heteroaryloxy, -OH, OR7, -C (O ) OR7, -OC (O) R7-, -N (R7) 2, -N (R7) C (O) R7, -N (R7) C (O) OR7, -NO2 and -CN, where each of said alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl can be independently unsubstituted or substituted with one or more substituents that may be the same or different and are independently selected from the group consisting of halogen, -OH, alkoxy, haloalkoxy, alkyl , haloalkyl, alkoxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, aryl, aryloxy, heteroaryl, heteroaryloxy, -N (R7) 2, -C (O) R7, -C (O) OR7, -OC (O) R7, - C (O) N (R7) 2, -N (R7) C (O) R7, -N (R7) C (O) OR7, -N (R7) C (O) N (R7) 2, -NO2, -CN, -S (O2) R7, -S (O2) N (R7) 2, and -N (R7) C (= N-CN) NHR7; or X may be an oxide when A is selected from the group consisting of pyridyl, thiophenyl, thiazolyl, indolyl, azaindolyl, quinolyl, isoquinolinyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrimidinyl, cinolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, and benzothiyl; -N (R5) -L3-R6 can optionally form an annular system; and m is an integer from 0 to 4. |
| priorityDate | 2004-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 334.