abstract |
A 2- (diaza-bicyclo-alkyl) -pyrimidone derivative represented by formula (I) or one of its salts, one of its solvates or one of its hydrates: ** (See formula) ** in which: R1 represents a hydrogen atom, a C 1-6 alkyl group or a halogen atom; R2 represents a hydrogen atom, a C1-6 alkyl group optionally substituted with 1 to 4 substituents selected from a halogen atom, a hydroxyl group or a C1-4 alkoxy group; a perhalogenated C1-2 alkyl group, a benzyl group, a phenethyl group, a benzyloxycarbonyl group, a C1-4 alkoxycarbonyl group, a benzene ring, a naphthalene ring, a quinoline ring, a phthalazine ring, a ring of 5,6,7,8-tetrahydronaphthalene, a pyridine ring, an indole ring, a pyrrole ring, a thiophene ring, a benzenesulfonyl group, a benzoyl group, a pyridazine ring, a furan ring or a imidazole ring; the benzyl group, the phenethyl group, the benzyloxycarbonyl group, the benzenesulfonyl group, the benzoyl group and the rings being optionally substituted with 1 to 4 substituents selected from a C1-6 alkyl group, a benzene ring, a halogen atom, a perhalogenated C 1-2 alkyl group, a halogenated C 1-3 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group, a cyano group, an amino group, a C 1-6 monoalkylamino group or a C2-10 dialkylamino group; R3 represents a 2, 4 or 5-pyrimidine ring or a 2, 3 or 4-pyridine ring, the rings being optionally substituted with a C 1-4 alkyl group, a C 1-4 alkoxy group or a halogen atom ; R4 represents a C1-4 alkyl group optionally substituted with a hydroxyl group, a C1-4 alkoxy group or a halogen atom and n represents 1 or |